Immunology
Dimerization and auto-processing induce caspase-11 protease activation within the non-canonical inflammasomeThis study provides a detailed molecular mechanism for caspase-11 activation within the non-canonical inflammasome, giving new insight into host defence against cytosolic bacterial infection.
Extracellular vesicles from mature dendritic cells (DC) differentiate monocytes into immature DCMature dendritic cells (DC) secrete substantial amounts of vesicles that are primarily ingested by monocytes, leading to differentiation processes in these target cells towards monocyte-derived DC.
Dynamic reorganisation of intermediate filaments coordinates early B-cell activationThis study examines the role of vimentin, a type III intermediate filament, in B-cell function using a combination of in vitro and in vivo assays, including super-resolution microscopic techniques.
Immunoediting is not a primary transformation event in a murine model of MLL-ENL AMLUsing a conditional model of MLL-ENL–driven AML, Dudenhöffer-Pfeifer and Bryder show that NK cell and adaptive immunity influences little on leukemia initiation from normal cells. The data argue against immune escape as a universal primary transformation event in AML.
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivoT follicular helper cells that secrete IL-4 accumulate in lymphoid organs in IgG4-related disease and are linked to IgG4 class switching.