Immunology
- Chemokine receptor hetero-oligomers regulate monocyte chemotaxis
Many chemokine receptors in human monocytes function within hetero-oligomeric complexes with α1-adrenoceptors and arginine vasopressin receptor 1A through which the chemokine receptor heteromerization partners are regulated.
- Dual neutrophil subsets exacerbate or suppress inflammation in tuberculosis via IL-1β or PD-L1
Neutrophils, key cells in tuberculosis, reach the lungs as two distinct subsets playing opposite roles in inflammation: either exacerbating via IL-1b or dampening via PD-L1.
- Full-length MSP1 is a major target of protective immunity after controlled human malaria infection
Full-length merozoite surface protein 1 is an important target of functional antibodies that play an important role in clinical immunity against invasive asexual Plasmodium falciparum parasites.
- Human T-cell activation with Toxoplasma gondii antigens loaded in maltodextrin nanoparticles
In this study, we investigated the human immune profile of T-cell subsets activated by a novel maltodextrin nanoparticle conjugated to Toxoplasma gondii antigen.
- The immune and microbial homeostasis determines the Candida–mast cells cross-talk in celiac disease
This study shows that the restoration of immune and microbial homeostasis promotes a beneficial Candida albicans–MC cross-talk attenuating the intestinal pathology in celiac disease.
- DEFA1A3 DNA gene-dosage regulates the kidney innate immune response during upper urinary tract infection
α-Defensin 1-3 (DEFA1A3) are host antimicrobial peptides with potent innate immune functions during infectious diseases. Differential UTI risk has been linked to DEFA1A3 DNA polymorphisms. This study elucidates mechanisms of DEFA1A3 gene dose–dependent protection against UTI pathogenesis.
- Type I interferon regulates interleukin-1beta and IL-18 production and secretion in human macrophages
Interferon type I modulates the gene expression of inflammasome-related genes and reduces cytokine release induced by NLRP3 inflammasome activation in human macrophages in vitro.
- CXCR4: from B-cell development to B cell–mediated diseases
This review provides an overview of the role of the C-X-C chemokine receptor type 4 (CXCR4) in B-cell development and in B cell–mediated disorders.
- Novel chemotype NLRP3 inhibitors that target the CRID3-binding pocket with high potency
The NLRP3 inflammasome drives various diseases. Here, we describe novel potent and selective NLRP3-targeted inhibitors to bolster pharmacological studies and development of NLRP3-targeted therapies.
- Reverse-engineering the anti-MUC1 antibody 139H2 by mass spectrometry–based de novo sequencing
A widely used anti-MUC1 antibody (139H2) is sequenced by mass spectrometry, revealing the molecular basis of its glycosylation-independent binding to this tumor-associated antigen.