Immunology
Retraction: Chitinase 1 regulates pulmonary fibrosis by modulating TGF-β/SMAD7 pathway via TGFBRAP1 and FOXO3Chitinase 1 (CHIT1) plays a role in the pathogenesis of pulmonary fibrosis by modulating canonical and noncanonical TGF-β signaling via interaction with TGFBRAP1 and FOXO3. These findings highlight the CHIT1/SMAD7 axis as a potential biomarker and therapeutic target of pulmonary fibrosis.
Development of a new monoclonal antibody specific to mouse Vγ6 chainUsing a novel mAb specific to Vγ6 TCR, we find Vγ6+ γδT cells are located in association with medullary thymic epithelial cells and play crucial roles in protection against Klebsiella pneumoniae infection but are pathogenic in psoriasis-like dermatitis in agreement with earlier studies.
A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesisOur study highlights a dual role for SAMHD1 in regulating hepatitis B virus cccDNA levels and reverse transcriptase–dependent particle genesis.
Functional inhibition of acid sphingomyelinase disrupts infection by intracellular bacterial pathogensMany intracellular pathogens hijack cholesterol. Inhibiting acid sphingomyelinase alters cholesterol traffic to target different intracellular bacteria, signifying a host-directed approach for treating infectious disease.
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejectionTargeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo.
Worldwide genetic variation of the IGHV and TRBV immune receptor gene families in humansThis article presents a comprehensive study of the IGHV and TRBV gene families in a globally diverse sample of humans and shows that the two gene families exhibit starkly different patterns of variation.
MiR-146a wild-type 3′ sequence identity is dispensable for proper innate immune function in vivoMice engineered to express an allele of a mammalian microRNA in which the 3′ paring specificity of the mature miRNA is robustly altered are phenotypically indistinguishable from mice with the wild-type allele.
Mucosa-associated microbiota drives pathogenic functions in IBD-derived intestinal iNKT cellsPro-inflammatory iNKT cells are enriched in IBD patients’ lamina propria. Exposure to the mucosa-associated microbiota drives their activation, inducing pathogenic activities against the epithelium.
DPP8/DPP9 inhibition elicits canonical Nlrp1b inflammasome hallmarks in murine macrophagesThis study shows that caspase-1 autocleavage, ASC speck assembly, and mature IL-1β and IL-18 secretion accompany rapid DPP8/DPP9-regulated pyroptosis induction in macrophages expressing a LeTx-responsive Nlrp1b allele.
Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and functionCostimulation of T cells through both TCR and STING induces growth inhibition by partially blocking the mTORC1 signals, and leads to IFN-I production through sustained activation of IRF3 and mTORC1 activation.