Immunology
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cellsThis comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signalingMAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMDCaspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.
IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitisIL-36 signaling in keratinocytes is crucial for Aldara-induced psoriasis-like dermatitis by controlling IL-23/IL-17A/IL-22 production and neutrophil recruitment at the third day of treatment.
Paneth cell α-defensin misfolding correlates with dysbiosis and ileitis in Crohn’s disease model miceThis study provides novel insight into Crohn’s disease where α-defensin misfolding resulting from excessive ER stress in Paneth cells induces dysbiosis and disease progression.
Immunoglobulin expression in the endoplasmic reticulum shapes the metabolic fitness of B lymphocytesImmunoglobulins shape mitochondrial function by driving ER expansion, this form of metabolic control is independent of the role the immunoglobulins play as part of the antigen receptor on the cell surface.
Dynamic changes in the regulatory T-cell heterogeneity and function by murine IL-2 muteinSingle-cell RNA-seq analysis reveals that IL-2 mutein treatment expands multiple sub-states of regulatory T cells with superior suppressive function in mice.
Keratinocyte interleukin-36 receptor expression orchestrates psoriasiform inflammation in miceIL-36 stimulation of keratinocytes orchestrates key pathogenic inflammatory responses in psoriatic skin.
Caspase-1 interdomain linker cleavage is required for pyroptosisThe related human NLRP1 and CARD8 form ASC-dependent and ASC-independent inflammasomes, respectively, both of which require pro-caspase-1 interdomain linker processing for the induction of pyroptosis.