Immunology
Methionine uptake via the SLC43A2 transporter is essential for regulatory T-cell survivalRegulatory T cells survive after IL-2 withdrawal by taking up and using methionine through the SLC43A2 transporter in a Notch1-dependent manner.
Cross talk between glucose metabolism and immunosuppression in IFN-γ–primed mesenchymal stem cellsThis study reveals a novel relationship between mesenchymal stem cell immunomodulation and metabolism and provides a new strategy to improve their therapeutic efficacy in inflammatory diseases.
Mechanistic and pharmacodynamic studies of DuoBody-CD3x5T4 in preclinical tumor modelsThis study provides in-depth insight into the mechanism of action and in vivo pharmacodynamic markers of a CD3x5T4 bispecific antibody in preclinical in vitro and in vivo solid cancer models.
HIV-1 infection enhances innate function and TLR7 expression in female plasmacytoid dendritic cellsThis study shows that the TLR7-driven innate function of pDCs is increased in HIV/ART women and is associated with enhanced expression of the TLR7 locus from both X chromosomes.
Semaphorin 6D–expressing mesenchymal cells regulate IL-10 production by ILC2s in the lungGroup 2 innate lymphoid cells (ILC2s) have features specific to the niches in which they reside, and we found that semaphorin 6D signaling in the lung niche controls IL-10 production by ILC2s.
Intestinal single-cell atlas reveals novel lymphocytes in pigs with similarities to human cellsSingle-cell RNA sequencing of porcine ileal lymphocytes reveals similarities to human cells and discovery of porcine intestinal innate lymphoid cells.
Efficacy of SARS-CoV-2 vaccination in patients with monoclonal gammopathies: A cross sectional studyUninfected multiple myeloma patients do not develop adequate immunity after SARS-COV-2 vaccination and will clearly benefit from tailored monitoring of immune responses after booster vaccine doses.
ScRNA-seq expression of IFI27 and APOC2 identifies four alveolar macrophage superclusters in healthy BALFThere are at least 14 AM subtypes; their frequency, along with other immune cells, is highly conserved across individuals, suggesting a specific niche exists for each leukocyte population.
Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertensionThe key pathogenic features of pulmonary hypertension are endothelial apoptosis and vascular inflammation, which are caused by the down-regulation of Amphiregulin, accompanied by HIF-1a and BAD-mediated up-regulation of the target genes such as RRP1B, PHB2, and NCOA6.
Autoreactive CD8 T cells in NOD mice exhibit phenotypic heterogeneity but restricted TCR gene usagePaired scRNA-seq and scTCR-seq reveals that diabetogenic CD8 T cells in the islets and spleens of NOD mice exhibit phenotypic and clonal heterogeneity despite restricted TCR gene usage. Expression of certain TCR genes correlates with clonal proliferation and effector phenotype.