Immunology
- Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells
Tissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.
- High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patients
High-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients.
- A serum proteome signature to predict mortality in severe COVID-19 patients
A serum proteome panel, which includes several type-3 cystatins and inter-α-trypsin inhibitors, predicts mortality in severe COVID-19 patients very well, in three independent cohorts.
- Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venules
Intravital imaging reveals stepwise transmigration cascade of T- and B cells across endothelial cells and fibroblastic reticular cells in lymph node high endothelial venules via hot spots.
- Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancy
The current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
- Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detection
ATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.
- IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infection
IL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.
- iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hosts
Immunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.
- Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral response
This work highlights the multifunctional role of the ISG viperin and its interaction with the peroxisomal protein Pex19 to modulate peroxisomal-dependent innate signaling that ultimately restricts viral infection.
- Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction
Endogenous and heterologpusly expressed human IFITM3 restricts early and late replication steps of chikungunya and Mayaro virus infection and is downregulated at the protein level in infected cells.