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Immunology

  • PGE<sub>2</sub> accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking
    Open Access
    PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smoking

    Loka R Penke, Jennifer M Speth, Christina Draijer, Zbigniew Zaslona, Judy Chen, Peter Mancuso, Christine M Freeman, Jeffrey L Curtis, Daniel R Goldstein, Marc Peters-Golden

    Loka R Penke ... Marc Peters-Golden

    Published 20 August 2020

    Dysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could explain opposite effects on AM numbers.

  • Thymosin α1 protects from CTLA-4 intestinal immunopathology
    Open Access
    Thymosin α1 protects from CTLA-4 intestinal immunopathology

    Giorgia Renga, Marina M Bellet, Marilena Pariano, Marco Gargaro, Claudia Stincardini, Fiorella D’Onofrio, Paolo Mosci, Stefano Brancorsini, Andrea Bartoli, Allan L Goldstein, Enrico Garaci, Luigina Romani, Claudio Costantini

    Giorgia Renga ... Claudio Costantini

    Published 14 August 2020

    This study demonstrates that Tα1 protects mice from anti–CTLA-4–induced colitis and sustains its antitumor activity, thus suggesting that Tα1 may be used in combination protocols.

  • Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1<sup>high</sup> memory phenotype CD4 T cells
    Open Access
    Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cells

    Alistair LJ Symonds, Wei Zheng, Tizong Miao, Haiyu Wang, TieShang Wang, Ruth Kiome, Xiujuan Hou, Suling Li, Ping Wang

    Alistair LJ Symonds ... Ping Wang

    Published 24 July 2020

    PD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.

  • Attenuation of cGAS/STING activity during mitosis
    Open Access
    Attenuation of cGAS/STING activity during mitosis

    Brittany L Uhlorn, Eduardo R Gamez, Shuaizhi Li, Samuel K Campos

    Brittany L Uhlorn ... Samuel K Campos

    Published 13 July 2020

    To limit deleterious interferon responses with each cell division and open mitosis, cGAS/STING activities are shown to be dampened-with Golgi vesiculation preventing activation of STING.

  • EBV renders B cells susceptible to HIV-1 in humanized mice
    Open Access
    EBV renders B cells susceptible to HIV-1 in humanized mice

    Donal McHugh, Renier Myburgh, Nicole Caduff, Michael Spohn, Yik Lim Kok, Christian W Keller, Anita Murer, Bithi Chatterjee, Julia Rühl, Christine Engelmann, Obinna Chijioke, Isaak Quast, Mohaned Shilaih, Victoria P Strouvelle, Kathrin Neumann, Thomas Menter, Stephan Dirnhofer, Janice KP Lam, Kwai F Hui, Simon Bredl, Erika Schlaepfer, Silvia Sorce, Andrea Zbinden, Riccarda Capaul, Jan D Lünemann, Adriano Aguzzi, Alan KS Chiang, Werner Kempf, Alexandra Trkola, Karin J Metzner, Markus G Manz, Adam Grundhoff, Roberto F Speck, Christian Münz

    Donal McHugh ... Christian Münz

    Published 23 June 2020

    A proportion of EBV+ B cells are infectible by CXCR4-tropic HIV-1 in vitro and in vivo, and these HIV-infected B cells can transmit infection to previously virus-naïve humanized mice.

  • Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells
    Open Access
    Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cells

    Melissa M Gresle, Margaret A Jordan, Jim Stankovich, Tim Spelman, Laura J Johnson, Louise Laverick, Alison Hamlett, Letitia D Smith, Vilija G Jokubaitis, Josephine Baker, Jodi Haartsen, Bruce Taylor, Jac Charlesworth, Melanie Bahlo, Terence P Speed, Matthew A Brown, Judith Field, Alan G Baxter, Helmut Butzkueven

    Melissa M Gresle ... Helmut Butzkueven

    Published 9 June 2020

    This comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.

  • Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer
    Open Access
    Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancer

    Alaknanda Adwal, Priyakshi Kalita-de Croft, Reshma Shakya, Malcolm Lim, Emarene Kalaw, Lucinda D Taege, Amy E McCart Reed, Sunil R Lakhani, David F Callen, Jodi M Saunus

    Alaknanda Adwal ... Jodi M Saunus

    Published 18 May 2020

    Engaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.

  • MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling
    Open Access
    MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signaling

    Hoi-Lam Ngan, Yuchen Liu, Andrew Yuon Fong, Peony Hiu Yan Poon, Chun Kit Yeung, Sharon Suet Man Chan, Alexandria Lau, Wenying Piao, Hui Li, Jessie Sze Wing Tse, Kwok-Wai Lo, Sze Man Chan, Yu-Xiong Su, Jason Ying Kuen Chan, Chin Wang Lau, Gordon B Mills, Jennifer Rubin Grandis, Vivian Wai Yan Lui

    Hoi-Lam Ngan ... Vivian Wai Yan Lui

    Published 7 May 2020

    MAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.

  • Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
    Open Access
    Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

    Rosalie Heilig, Marisa Dilucca, Dave Boucher, Kaiwen W Chen, Dora Hancz, Benjamin Demarco, Kateryna Shkarina, Petr Broz

    Rosalie Heilig ... Petr Broz

    Published 28 April 2020

    Caspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.

  • IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis
    Open Access
    IL-36 signaling in keratinocytes controls early IL-23 production in psoriasis-like dermatitis

    Jérémie D Goldstein, Esen Y Bassoy, Assunta Caruso, Jennifer Palomo, Emiliana Rodriguez, Sylvain Lemeille, Cem Gabay

    Jérémie D Goldstein ... Cem Gabay

    Published 28 April 2020

    IL-36 signaling in keratinocytes is crucial for Aldara-induced psoriasis-like dermatitis by controlling IL-23/IL-17A/IL-22 production and neutrophil recruitment at the third day of treatment.

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