Immunology
- Distinct groups of autoantigens as drivers of ocular adnexal MALT lymphoma pathogenesis
B-cell self-stimulation and local autoimmune reactions are instrumental in the pathogenesis of a substantial fraction of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas.
- FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretion
The ubiquitin-like modifier FAT10 down-regulates the antiviral type-I IFN response not only by targeting OTUB1 but also by degrading the E3 TRIM21 and by inhibiting its activation upon IAV infection.
- Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation
STAT3 and c-SKI repress SMAD3 to induce cDC differentiation.
- Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol
Mitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. This export pathway is detected in a subset of lung cancer cell lines.
- The transcription factor HIF-1α in NKp46+ ILCs limits chronic intestinal inflammation and fibrosis
ILC1 activation by the oxygen-sensitive transcription factor HIF-1α is detrimental upon acute colitis, but protects against inflammation and fibrosis during chronic colitis.
- Correction: Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing
Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.
- Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity
Transient PU.1low fetal progenitors generate activated and memory T and B cells that colonize and are maintained in secondary lymphoid tissues and make an early and long-term contribution to the adult immune system.
- Crosstalk between Regnase-1 and -3 shapes mast cell survival and cytokine expression
The RNA-binding proteins Regnase-1 and -3 are central co-regulators of mast cell inflammatory responses. Specifically, Regnase-1 affects mast cell survival and proliferation; instead, both Regnases modulate the expression of inflammatory molecules, with the cytokine TNF being a primary target.
- Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing
Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.
- Chemokine receptor hetero-oligomers regulate monocyte chemotaxis
Many chemokine receptors in human monocytes function within hetero-oligomeric complexes with α1-adrenoceptors and arginine vasopressin receptor 1A through which the chemokine receptor heteromerization partners are regulated.