Immunology
The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cellsMHC-I internalization and recycling in DCs neither requires Arf6 nor provides MHC-I to the Rab11+ endocytic recycling compartment; however, cross-presentation of immune complexes depends on Arf6.
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapyInhibition of active MMP9 early during tumorigenesis suppresses tumor cell migration, invasion, and colony formation and tilts the balance towards anti-tumor immunity by activating CD8+ T cells.
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous diseaseThis study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.
![Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice](https://www.life-science-alliance.org/sites/default/files/styles/lsa_thumbnail_image/public/externals/1826ba9c9b29cdb17704ada32e87ee01.jpg?itok=uRNfFQLZ)
Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] miceThis article shows that liver and kidney damage in a lupus-prone mouse line occurs by different mechanisms and that only drugs targeting core components of signaling pathway, such as IRAK4, are able to suppress all facets of the disease.
Conservation of cell-intrinsic immune responses in diverse nonhuman primate speciesThe transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.
Ligand-induced IFNGR1 down-regulation calibrates myeloid cell IFNγ responsivenessIFNγ is shown to silence Ifngr1 transcription by altering enhancer occupancy, reducing myeloid cell IFNGR1 as a feedback mechanism to attenuate macrophage responses associated with inflammation.
Reconstructing B-cell receptor sequences from short-read single-cell RNA sequencing with BRAPeSBRAPeS is a software for B-cell receptor reconstruction in single cells from very short (25–30 bp) read lengths, which achieves similar success rates and accuracy as applying other methods on long reads.
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structuresThis study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.
Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapyBlocking NOX1 with the novel small molecule inhibitor GKT771 inhibits tumor growth in mice by targeting tumor lymph/angiogenesis and promoting antitumor immune cells recruitment. GKT771 emerges as a novel and promising anticancer drug worth translating into the clinics.
Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLCUsing an immunocompetent mouse model of NSCLC, this study demonstrates that tumor-intrinsic response to IFNγ determines response to anti–PD-1 through alterations in the tumor microenvironment.