Immunology
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancyThe current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detectionATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infectionIL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.
iNKT cells coordinate immune pathways to enable engraftment in nonconditioned hostsImmunotherapeutic iNKT cells interact with monocytes and T cells in human umbilical cord blood grafts to simultaneously limit inflammation while promoting hematopoietic activity.
Viperin interacts with PEX19 to mediate peroxisomal augmentation of the innate antiviral responseThis work highlights the multifunctional role of the ISG viperin and its interaction with the peroxisomal protein Pex19 to modulate peroxisomal-dependent innate signaling that ultimately restricts viral infection.
Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteractionEndogenous and heterologpusly expressed human IFITM3 restricts early and late replication steps of chikungunya and Mayaro virus infection and is downregulated at the protein level in infected cells.
Single-cell RNA sequencing of mouse islets exposed to proinflammatory cytokinesSingle-cell RNA-seq was used to show that islet endocrine cells respond to acute cytokine exposure with an increase in the expression of protective genes and the absence of apoptotic gene expression.
NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammationTNFR1 was found to cause skin inflammation in mice with epidermal keratinocyte-specific ablation of IKK2 or of both the NF-kB subunits RelA and cRel by triggering RIPK1-dependent, RIPK3-MLKL–mediated necroptosis of keratinocytes.
Proteomics characterisation of the L929 cell supernatant and its role in BMDM differentiationL929 cell supernatant is commonly used to differentiate murine macrophages from bone marrow. The supernatant and its effect on macrophage phenotype was characterised by proteomics and the authors identified novel immunoregulatory proteins.
DGCR8 deficiency impairs macrophage growth and unleashes the interferon response to mycobacteriaLack of miRNA biosynthesis in DGCR8-deficient macrophages did not block macrophage differentiation but caused overshooting type I IFN responses to mycobacterial glycolipids.