Immunology
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in ratsLiver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasmaUsing microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.
TANK prevents IFN-dependent fatal diffuse alveolar hemorrhage by suppressing DNA-cGAS aggregationDiffuse alveolar hemorrhage developed in an SLE mouse model is ameliorated by TANK via the suppression of type I IFN induced by cGAS-mediated sensing of intracellular DNA.
TICAM-1/TRIF associates with Act1 and suppresses IL-17 receptor–mediated inflammatory responsesTICAM-1/TRIF, a TLR3 adaptor molecule, associates with Act1 to inhibit the interaction between IL-17RA and Act1, resulting in attenuated IL-17-mediated inflammatory responses.
Integrated stress response restricts macrophage necroptosisStress inhibits necroptosis in a PERK-dependent manner via reduced RIPK1-RIPK3-MLKL signaling, showing an integral mechanistic connection between stress responses and programmed cell death.
Microbiota regulates the turnover kinetics of gut macrophages in health and inflammationMaintenance of the gut lamina propria–resident macrophage cell pool requires monocyte input during adulthood. Here, Ruedl and colleagues demonstrate that the intestinal microbiome positively influences the replenishment of tissue-resident macrophages under both steady-state and inflammatory conditions.
SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cellsSATB1 regulates mitochondrial function and reactive oxygen species (ROS) production through the expression of mitochondrial transcription factor A. SATB1-mediated ROS production is necessary for TCR stimulation and T-cell function.
Functional and metabolic fitness of human CD4+ T lymphocytes during metabolic stressHuman T-cell activation, expansion, and effector function is grossly impaired in conditions that combine glucose deprivation and mild mitochondrial stress.
MKP-1 modulates ubiquitination/phosphorylation of TLR signalingMKP-1 is a dual-specific phosphatase best known to dephosphorylate p38 and JNK. This study shows for the first time that MKP-1 modulates the landscape of ubiquitin ligases (TRAF6) and deubiquitinase enzymes, as well as upstream TLR signaling molecules.
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infectionCytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.