Immunology
Identification of single-cell blasts in pediatric acute myeloid leukemia using an autoencoderThe authors present a novel automated approach for the identification of blasts and their developmental stage in a longitudinal pediatric acute myeloid leukemia (AML) cohort. KMT2A-rearranged AMLs show unstable immunophenotype, with most patients presenting a more differentiated phenotype at relapse.
Reprogramming of breast tumor–associated macrophages with modulation of arginine metabolismA shift of arginine metabolism from polyamine synthesis to nitric oxide synthesis induces reprogramming of macrophages from pro-tumor M2 to anti-tumor M1 types.
Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regenerationA helminth-derived protein leads to rapid wound closure, skin regeneration, and reprogramming of macrophage activation through TGF-βR binding.
Neutrophil-avid nanocarrier uptake by STAT3 dominant-negative hyper-IgE syndrome patient neutrophilsRecurrent infections are a hallmark of STAT3 DN hyper-IgE syndrome, a rare immunodeficiency syndrome, and our study suggests that neutrophil-avid nanocarriers have potential for directed delivery of cargo therapeutics to improve neutrophil infection clearance in these patients.
Gene expression and chromatin conformation of microglia in virally suppressed people with HIVLeveraging our rapid autopsy “Last Gift” cohort at UCSD, we identified distinct microglial gene expression profiles despite ART.
Distinct groups of autoantigens as drivers of ocular adnexal MALT lymphoma pathogenesisB-cell self-stimulation and local autoimmune reactions are instrumental in the pathogenesis of a substantial fraction of ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas.
FAT10 inhibits TRIM21 to down-regulate antiviral type-I interferon secretionThe ubiquitin-like modifier FAT10 down-regulates the antiviral type-I IFN response not only by targeting OTUB1 but also by degrading the E3 TRIM21 and by inhibiting its activation upon IAV infection.
Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiationSTAT3 and c-SKI repress SMAD3 to induce cDC differentiation.
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosolMitochondrial double-stranded RNA is a new signaling molecule that, likely under stress conditions, is exported to induce a type 1 interferon response, thus mimicking a viral response. This export pathway is detected in a subset of lung cancer cell lines.
- Correction: Reduced protein-coding transcript diversity in severe dengue emphasises the role of alternative splicing
Transcriptomic analysis of dengue-infected patients reveals altered immune response pathways, transcript diversity, and splicing efficiency, underscoring potential therapeutic targets for treatment.