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Immunology

  • The Ragulator complex and lysosomal calcium release are crucial for cell migration
    Open Access
    The Ragulator complex and lysosomal calcium release are crucial for cell migration

    Tatsunori Jo, Kohei Tsujimoto, Takeshi Nakatani, Daiki Nagira, Yutaka Muto, Takehiro Hirayama, Hachiro Konaka, Masato Okada, Hyota Takamatsu, Atsushi Kumanogoh

    Tatsunori Jo ... Atsushi Kumanogoh

    Published 10 June 2025

    Lysosomal calcium efflux via TRPML1 drives leukocyte migration by enhancing Lamtor1–MPRIP interaction, and ouabain improves pathogenic inflammation by disrupting Lamtor1’s lysosomal localization.

  • C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation
    Open Access
    C-terminal binding protein 2 interacts with JUNB to control macrophage inflammation

    Benjamin A Strickland, Antonia Babl, Lena Wolff, Priya Singh, Marika E Friano, Franziska Greulich, N Henriette Uhlenhaut

    Benjamin A Strickland ... N Henriette Uhlenhaut

    Published 9 June 2025

    This study identifies CTBP2 as an oligomerization-dependent bridge between pro-inflammatory transcription factors and co-repressors that balances the expression of inflammatory genes.

  • Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release
    Open Access
    Inhibition of xanthine oxidoreductase with febuxostat, but not allopurinol, prevents inflammasome assembly and IL-1β release

    Lauar de Brito Monteiro, Anne-Sophie Archambault, Lucas F Starchuk, Armando Alcazar, Ju Hee Oh, Joshua A Dubland, Bojana Rakić, Annette E Patterson, C Bruce Verchere, Ramon I Klein Geltink

    Lauar de Brito Monteiro ... Ramon I Klein Geltink

    Published 21 May 2025

    This study focuses on the underappreciated distinct effects of two clinically used xanthine oxidoreductase inhibitors: allopurinol and febuxostat. Besides reducing uric acid levels in gout treatment, febuxostat, but not allopurinol, prevents NLRP3 inflammasome assembly and blocks IL-1β production by macrophages.

  • STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs
    Open Access
    STAT5B leukemic mutations, altering SH2 tyrosine 665, have opposing impacts on immune gene programs

    Hye Kyung Lee, Jichun Chen, Rachael L Philips, Sung-Gwon Lee, Xingmin Feng, Zhijie Wu, Chengyu Liu, Aaron B Schultz, Molly Dalzell, Manja Meggendorfer, Claudia Haferlach, Foster Birnbaum, Joel A Sexton, Amy E Keating, John J O’Shea, Neal S Young, Alejandro V Villarino, Priscilla A Furth, Lothar Hennighausen

    Hye Kyung Lee ... Lothar Hennighausen

    Published 14 April 2025

    Germline activating and deactivating mutations of STAT5b, part of the JAK-STAT signaling pathway, push the immune system and hematopoiesis in opposing directions, tuning systems either up or down.

  • Adenosine-generating CD39<sup>+</sup> plasmablasts predispose to successful infliximab therapy in pediatric IBD
    Open Access
    Adenosine-generating CD39+ plasmablasts predispose to successful infliximab therapy in pediatric IBD

    Alexander Schnell, Benedikt Schwarz, Hannah Schmidt, Ida Allabauer, Wolfgang Schuh, Adrian P Regensburger, Manfred Rauh, Joachim Woelfle, André Hoerning

    Alexander Schnell ... André Hoerning

    Published 8 April 2025

    IFX responders showed increased CD39 expression on plasmablasts and higher levels of CD39/CD73 co-expression on naïve and memory B cells, along with enhanced ATP degradation and adenosine production before treatment. Response was associated with increased IL10-producing plasmablasts and α4β7hi plasmablasts.

  • The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation
    Open Access
    The MFN2 Q367H variant reveals a novel pathomechanism connected to mtDNA-mediated inflammation

    Mashiat Zaman, Govinda Sharma, Walaa Almutawa, Tyler GB Soule, Rasha Sabouny, Matt Joel, Armaan Mohan, Cole Chute, Jeffrey T Joseph, Gerald Pfeffer, Timothy E Shutt

    Mashiat Zaman ... Timothy E Shutt

    Published 2 April 2025

    The present study describes a novel pathogenic variant in MFN2 from a patient with late-onset distal myopathy and links pathogenic perturbation of MFN2 function to mitochondrial DNA release and inflammation.

  • FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis
    Open Access
    FGF7 as an essential mediator for the onset of ankylosing enthesitis related to psoriatic dermatitis

    Shin Ebihara, Yuji Owada, Masao Ono

    Shin Ebihara ... Masao Ono

    Published 7 February 2025

    This study sheds light on the pathogenic association between the skin and joints in psoriatic arthritis. The authors indicated that IL-17A, which is produced in the skin, induces joint manifestations via FGF7 signaling in the pathology of psoriatic arthritis.

  • UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia
    Open Access
    UNC119 regulates T-cell receptor signalling in primary T cells and T acute lymphocytic leukaemia

    Youhani Samarakoon, Tamas Yelland, Esther Garcia-Gonzalez, Amauri da Silva Justo Junior, Mahnoor Mahmood, Anand Manoharan, Shaun Patterson, Valentina Serafin, Payam A Gammage, Sandra Marmiroli, Christina Halsey, Shehab Ismail, Edward W Roberts

    Youhani Samarakoon ... Edward W Roberts

    Published 15 January 2025

    Inhibiting the ciliary protein UNC119 in primary T cells alters LCK localisation and function independently of the phosphorylation state. UNC119 also may represent a therapeutic target in T acute lymphocytic leukaemia as UNC119 inhibition reduced cancer cell growth.

  • lncRNA <em>CARINH</em> regulates expression and function of innate immune transcription factor IRF1 in macrophages
    Open Access
    lncRNA CARINH regulates expression and function of innate immune transcription factor IRF1 in macrophages

    Yannick Cyr, Morgane Gourvest, Grace O Ciabattoni, Tracy Zhang, Alexandra AC Newman, Tarik Zahr, Sofie Delbare, Florencia Schlamp, Meike Dittmann, Kathryn J Moore, Coen van Solingen

    Yannick Cyr ... Coen van Solingen

    Published 7 January 2025

    The antisense lncRNA CARINH acts as an additional regulatory layer of antiviral immunity through coordinated regulation of the transcription factor IRF1 and downstream interferon-stimulated genes.

  • Molecular analysis of acute pyelonephritis—excessive innate and attenuated adaptive immunity
    Open Access
    Molecular analysis of acute pyelonephritis—excessive innate and attenuated adaptive immunity

    Ines Ambite, Sing Ming Chao, Therese Rosenblad, Richard Hopkins, Petter Storm, Yong Hong Ng, Indra Ganesan, Magnus Lindén, Farhan Haq, Thi Hien Tran, Shahram Ahmadi, Bernett Lee, Swaine L Chen, Gabriela Godaly, Per Brandström, John E Connolly, Catharina Svanborg

    Ines Ambite ... Catharina Svanborg

    Published 20 December 2024

    Characteristics of a cytokine storm, with hyper-activated innate immunity and attenuated adaptive immunity in infants with acute pyelonephritis, defined by gene expression, urine protein, and exome sequence analysis.

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