Immunology
Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2sThe transcriptional mechanisms for Satb1 gene expression are ill-defined. This study identifies a novel enhancer for Satb1 expression in TH2 cells and to suppress IL-5 production, and for Satb1 expression in activated ILC2s.
FAT10 and NUB1L cooperate to activate the 26S proteasome26S proteasome activation is achieved by the collective binding of the ubiquitin-like modifier FAT10 and its interaction partner NUB1L, causing gate opening in a USP14-independent way.
Myc controls NK cell development, IL-15-driven expansion, and translational machineryMyc ablation in vivo impacts immature NK cells’ ribosomagenesis and development. Accordingly, mice with NK cells lacking Myc exhibit impaired anticancer immunity.
The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligandThe lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.
The pro-inflammatory response to influenza A virus infection is fueled by endothelial cellsA co-culture model of human primary endothelial cells and organoid-derived epithelial cells shows that endothelial cells are abortively infected by influenza A virus but can drive the pro-inflammatory response.
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infectionA soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.
An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicityThis work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxinsFBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.
Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjectsSARS-CoV-2-specific T-cells from convalescent donors present phenotypical and functional characteristics that make them a suitable candidate for a future development of an advanced cellular therapy.
Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipientsThe prophylactic use of defibrotide in pediatric HSCT recipients significantly reduces the incidence and severity of acute GVHD, with a modification of cytokine pattern, both strongly coherent with the protective drug’s action.