Immunology
OXSR1 inhibits inflammasome activation by limiting potassium efflux during mycobacterial infectionMycobacteria up-regulate host kinase OXSR1 preventing potassium efflux and inflammasome activation. Depletion or inhibition of OXSR1 potentiates inflammasome activation and decreases bacterial burden.
Fluorescent tracking identifies key migratory dendritic cells in the lymph node after radiotherapyRadiation therapy impacts all cells within the treatment field. Using novel technology, we track dendritic cells from the tumor to lymph nodes and demonstrate their importance in immune control of tumors.
The miR-26 family regulates early B cell development and transformationWe show that the activity of the miR-26 family determines early B cell behavior: high miR-26 levels promote cell expansion and block the pre-B to immature B cell transition, whereas a miR-26 reduction limits expansion and enhances pre-B cell differentiation.
mRNA COVID-19 vaccine booster fosters B- and T-cell responses in immunocompromised patientsImmunocompromised patients poorly respond to two doses of SARS-CoV-2 mRNA vaccines. However, an additional booster dose elicits a strong humoral and cellular immune response in these subjects.
Malaria abrogates O’nyong–nyong virus pathologies by restricting virus infection in nonimmune cellsThis study reveals that acute blood-stage malaria promotes resistance to ONNV infection by inducing IFNg-dependent antiviral status in human and murine nonimmune cells.
Gene-selective transcription promotes the inhibition of tissue reparative macrophages by TNFPro-inflammatory TNF is a highly gene-selective inhibitor of the gene expression program of tissue repair and wound healing macrophages.
ADAR1 RNA editing regulates endothelial cell functions via the MDA-5 RNA sensing signaling pathwayCellular RNA transcripts in endothelial cells, especially the SINE RNAs, need extensive editing by the A-to-I RNA editing enzyme ADAR1, which is essential for neonatal survival by regulating the MDA-5–mediated RNA-sensing signaling pathway.
Generation of human long-lived plasma cells by developmentally regulated epigenetic imprintingThis study shows that the generation of human long-lived plasma cells requires blood antibody secreting cells to undergo epigenetic and transcriptional reprogramming in response to the bone marrow microniche to become apoptosis resistant and survive to secrete antibodies for a lifetime.
Transcriptomics reveals immune-metabolism disorder in acute-on-chronic liver failure in ratsLiver tissue transcriptomics of liver cirrhosis (LC)–based acute-on-chronic liver failure (ACLF) rats reveal immune-metabolism disorder as the core mechanism underlying ACLF development and prognosis.
Microfluidic characterisation reveals broad range of SARS-CoV-2 antibody affinity in human plasmaUsing microfluidic affinity profiling, we show how the antibody affinity varies significantly between different individuals after COVID-19 infection while the antibodies neutralise the virus.