Immunology
RNA helicase EIF4A1-mediated translation is essential for the GC responseConditional mouse knock-out models show that EIF4A1, but not its cofactors EIF4B or EIF4H, is essential in B cells for their development, the GC response, and increased translation after activation.
FAT10 is phosphorylated by IKKβ to inhibit the antiviral type-I interferon responseIKKβ-mediated phosphorylation of FAT10 dampens the antiviral type I interferon response by stabilizing OTUB1.
Immunosuppressive low-density neutrophils in the blood of cancer patients display a mature phenotypeLow-density neutrophils (LDN) in cancer patient’s blood are heterogeneous: CD45high LDN are mature and suppress T-cell proliferation, whereas CD45low LDN are immature and non-suppressive.
Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammationSimultaneous deficiency of three tristetraprolin family members in myeloid cells resulted in severe inflammation in mice, suggesting that these three proteins act together to prevent inflammation.
APR-246 increases tumor antigenicity independent of p53Michels, Venkatesh et al demonstrate that APR-246, a small molecule Michael acceptor, enhances tumor immunogenicity. Combination of APR-246 with immune modulation enhances antitumor responses. APR-246, initially described as a P53 stabilizer, induces immunogenicity irrespective of the tumor’s p53 status.
Assessing MAPPs assay as a tool to predict the immunogenicity potential of protein therapeuticsThis work highlights the use of streptavidin magnetic beads as a valuable approach for the immunoaffinity purification of mass spectrometry MHCII-eluted ligands (MAPPs) and their practical application in assessing the drug-induced immunogenicity risk of novel biotherapeutics.
The coenzyme A precursor pantethine enhances antitumor immunity in sarcomaVitB5 level becomes limiting in sarcomas. It is regulated by the pantetheinase activity of VNN1. VNN1 expression in sarcomas is associated with better prognosis and immune infiltration. In mouse, complementation with pantethine a vitB5 precursor boosts antitumor immunity.
Activation of the JNK/COX-2/HIF-1α axis promotes M1 macrophage via glycolytic shift in HIV-1 infectionThis study reveals JNK/COX-2/HIF-1α axis activation enhances glycolysis, promoting M1 polarization in HIV-1–infected macrophages, offering a novel approach to AIDS-related inflammation.
Peptide derived from SLAMF1 prevents TLR4-mediated inflammation in vitro and in vivoSLAMF1-derived peptide P7 inhibits TLR4-mediated signaling and prevents animal death in mice subjected to LPS shock by blocking TIRAP–MyD88 interaction and TRAM recruitment to TLR4.
Themis controls T cell activation, effector functions, and metabolism of peripheral CD8+ T cellsAcute deletion of Themis in peripheral CD8+ T cells shows Themis controls T cell receptor signaling, effector functions, and metabolism. Signal cascade adaptation occurred with chronic Themis deletion.