Immunology
- Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.
- Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.
- Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells
Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.
- Cx3cr1-deficient microglia exhibit a premature aging transcriptome
Gyoneva et al use RNA-seq to show that Cx3cr1-deficient microglia in young mice display a gene expression profile similar to microglia in aged mice, suggesting premature microglial aging.
- The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response
B cell–intrinsic AKT1/2 are essential for germinal center formation, antibody production and affinity maturation, and plasma cell differentiation.
- The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cells
MHC-I internalization and recycling in DCs neither requires Arf6 nor provides MHC-I to the Rab11+ endocytic recycling compartment; however, cross-presentation of immune complexes depends on Arf6.
- MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapy
Inhibition of active MMP9 early during tumorigenesis suppresses tumor cell migration, invasion, and colony formation and tilts the balance towards anti-tumor immunity by activating CD8+ T cells.
- Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous disease
This study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.
- Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice
This article shows that liver and kidney damage in a lupus-prone mouse line occurs by different mechanisms and that only drugs targeting core components of signaling pathway, such as IRAK4, are able to suppress all facets of the disease.
- Conservation of cell-intrinsic immune responses in diverse nonhuman primate species
The transcriptomic response of diverse nonhuman primate (NHP) species to poly(I:C) is highly conserved, and this novel RNA sequencing dataset will help improve NHP genome annotations.