Immunology
Elevated glycolysis imparts functional ability to CD8+ T cells in HIV infectionCytotoxic killer CD8+ T cells (CTLs) are central effectors that eliminate virus infected cells. In HIV infection, HIV-specific CTLs become functionally impaired. Herein we investigated the link between metabolism and CD8+ T-cell functional impairment, known as exhaustion.
The Th1 cell regulatory circuitry is largely conserved between human and mouseComparison of the binding sites of the Th1 lineage-specifying transcription factor T-bet between human and mouse reveals differences in binding sites but that the most of the target genes are shared.
Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19COVID-19 induces high levels of autoimmune anti-DNA and anti-phosphatidylserine antibodies that are detected in some patients upon hospital admission and predict later development of severe disease.
Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cellsTissue-resident memory (TRM) T cells in mouse and human melanoma-associated vitiligo skin form large lymphoid aggregates with CXCL16-expressing dendritic cells. CD11c depletion or disruption of the CXCR6-CXCL16 axis results in loss of skin TRM cells and tumor immunity.
High-dose intravenous immunoglobulins might modulate inflammation in COVID-19 patientsHigh-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients.
A serum proteome signature to predict mortality in severe COVID-19 patientsA serum proteome panel, which includes several type-3 cystatins and inter-α-trypsin inhibitors, predicts mortality in severe COVID-19 patients very well, in three independent cohorts.
Stepwise transmigration of T- and B cells through a perivascular channel in high endothelial venulesIntravital imaging reveals stepwise transmigration cascade of T- and B cells across endothelial cells and fibroblastic reticular cells in lymph node high endothelial venules via hot spots.
Macrophages-induced IL-18–mediated eosinophilia promotes characteristics of pancreatic malignancyThe current study presents first CP murine model that show IL-18–induced eosinophil inflammation-mediated induction of oncogenic proteins and several pathological malignant characteristics.
Profiling chromatin accessibility responses in human neutrophils with sensitive pathogen detectionATAC-seq reveals unique neutrophil chromatin architecture changes in response to different stimuli before transcriptional activation, possibly regulating downstream gene expression.
IL-13 deficiency exacerbates lung damage and impairs epithelial-derived type 2 molecules during nematode infectionIL-13 is tissue protective during acute lung injury caused by nematode migration and specifically regulates type 2 epithelial cell effector functions.