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Immunology

  • Identification of a novel enhancer essential for <em>Satb1</em> expression in T<sub>H</sub>2 cells and activated ILC2s
    Open Access
    Identification of a novel enhancer essential for Satb1 expression in TH2 cells and activated ILC2s

    Aneela Nomura, Tetsuro Kobayashi, Wooseok Seo, Michiko Ohno-Oishi, Kiyokazu Kakugawa, Sawako Muroi, Hideyuki Yoshida, Takaho A Endo, Kazuyo Moro, Ichiro Taniuchi

    Aneela Nomura ... Ichiro Taniuchi

    Published 16 May 2023

    The transcriptional mechanisms for Satb1 gene expression are ill-defined. This study identifies a novel enhancer for Satb1 expression in TH2 cells and to suppress IL-5 production, and for Satb1 expression in activated ILC2s.

  • FAT10 and NUB1L cooperate to activate the 26S proteasome
    Open Access
    FAT10 and NUB1L cooperate to activate the 26S proteasome

    Florian Brockmann, Nicola Catone, Christine Wünsch, Fabian Offensperger, Martin Scheffner, Gunter Schmidtke, Annette Aichem

    Florian Brockmann ... Annette Aichem

    Published 15 May 2023

    26S proteasome activation is achieved by the collective binding of the ubiquitin-like modifier FAT10 and its interaction partner NUB1L, causing gate opening in a USP14-independent way.

  • Myc controls NK cell development, IL-15-driven expansion, and translational machinery
    Open Access
    Myc controls NK cell development, IL-15-driven expansion, and translational machinery

    Hanif J Khameneh, Nicolas Fonta, Alessandro Zenobi, Charlène Niogret, Pedro Ventura, Concetta Guerra, Ivo Kwee, Andrea Rinaldi, Matteo Pecoraro, Roger Geiger, Andrea Cavalli, Francesco Bertoni, Eric Vivier, Andreas Trumpp, Greta Guarda

    Hanif J Khameneh ... Greta Guarda

    Published 27 April 2023

    Myc ablation in vivo impacts immature NK cells’ ribosomagenesis and development. Accordingly, mice with NK cells lacking Myc exhibit impaired anticancer immunity.

  • The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand
    Open Access
    The C-type lectin domain of CD62P (P-selectin) functions as an integrin ligand

    Yoko K Takada, Scott I Simon, Yoshikazu Takada

    Yoko K Takada ... Yoshikazu Takada

    Published 25 April 2023

    The lectin domain of CD62P specifically binds to and activates integrins. CD62P-integrin interactions may function in a diverse set of cell–cell adhesions given that integrins are widely expressed.

  • The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells
    Open Access
    The pro-inflammatory response to influenza A virus infection is fueled by endothelial cells

    Lisa Bauer, Laurine C Rijsbergen, Lonneke Leijten, Feline FW Benavides, Danny Noack, Mart M Lamers, Bart L Haagmans, Rory D de Vries, Rik L de Swart, Debby van Riel

    Lisa Bauer ... Debby van Riel

    Published 18 April 2023

    A co-culture model of human primary endothelial cells and organoid-derived epithelial cells shows that endothelial cells are abortively infected by influenza A virus but can drive the pro-inflammatory response.

  • Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection
    Open Access
    Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection

    Luise Hassler, Jan Wysocki, Jared T Ahrendsen, Minghao Ye, Ian Gelarden, Vlad Nicolaescu, Anastasia Tomatsidou, Haley Gula, Cosimo Cianfarini, Peter Forster, Nigar Khurram, Benjamin D Singer, Glenn Randall, Dominique Missiakas, Jack Henkin, Daniel Batlle

    Luise Hassler ... Daniel Batlle

    Published 11 April 2023

    A soluble ACE2 protein bioengineered to have extended duration of action and enhanced affinity for SARS-CoV-2 provides markedly improved survival and organ protection when administered intranasally. Reducing brain SARS-CoV-2 titers is an important determinant of therapeutic efficacy.

  • An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity
    Open Access
    An OMA1 redox site controls mitochondrial homeostasis, sarcoma growth, and immunogenicity

    Richard Miallot, Virginie Millet, Yann Groult, Angelika Modelska, Lydie Crescence, Sandrine Roulland, Sandrine Henri, Bernard Malissen, Nicolas Brouilly, Laurence Panicot-Dubois, Renaud Vincentelli, Gerlind Sulzenbacher, Pascal Finetti, Aurélie Dutour, Jean-Yves Blay, François Bertucci, Franck Galland, Philippe Naquet

    Richard Miallot ... Philippe Naquet

    Published 5 April 2023

    This work describes how a mutation affecting mitochondrial metabolism in a sarcoma model induces protective immunity against the tumor and how this result might be relevant for sarcoma patients.

  • FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins
    Open Access
    FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins

    Yusun Jeon, Seong H Chow, Isabella Stuart, Ashley Weir, Amy TY Yeung, Christine Hale, Sushmita Sridhar, Gordon Dougan, James E Vince, Thomas Naderer

    Yusun Jeon ... Thomas Naderer

    Published 28 March 2023

    FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins.

  • Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjects
    Open Access
    Potency assessment of IFNγ-producing SARS-CoV-2-specific T cells from COVID-19 convalescent subjects

    Rubén Gil-Bescós, Ainhoa Ostiz, Saioa Zalba, Ibai Tamayo, Eva Bandrés, Elvira Rojas-de-Miguel, Margarita Redondo, Amaya Zabalza, Natalia Ramírez

    Rubén Gil-Bescós ... Natalia Ramírez

    Published 20 March 2023

    SARS-CoV-2-specific T-cells from convalescent donors present phenotypical and functional characteristics that make them a suitable candidate for a future development of an advanced cellular therapy.

  • Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipients
    Open Access
    Defibrotide impact on the acute GVHD disease incidence in pediatric hematopoietic stem cell transplant recipients

    Domenica Squillaci, Annalisa Marcuzzi, Erika Rimondi, Guglielmo Riccio, Egidio Barbi, Davide Zanon, Natalia Maximova

    Domenica Squillaci ... Natalia Maximova

    Published 6 March 2023

    The prophylactic use of defibrotide in pediatric HSCT recipients significantly reduces the incidence and severity of acute GVHD, with a modification of cytokine pattern, both strongly coherent with the protective drug’s action.

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