Immunology
A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transitionAs human B-cells differentiate, IRF4 switches occupancy and acquires CTCF colocalisation and IRF4 regulatory output diverts from cell activation to plasma cell state genes in conjunction with XBP1, whereas BLIMP1 represses activation.
PGE2 accounts for bidirectional changes in alveolar macrophage self-renewal with aging and smokingDysregulation of self-renewal contributes to alterations in alveolar macrophages (AMs). In this study, Penke et al identify PGE2 as a suppressor of AM proliferation, whose divergent bioavailability in aged and cigarette smoke-exposed mice could explain opposite effects on AM numbers.
Thymosin α1 protects from CTLA-4 intestinal immunopathologyThis study demonstrates that Tα1 protects mice from anti–CTLA-4–induced colitis and sustains its antitumor activity, thus suggesting that Tα1 may be used in combination protocols.
Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1high memory phenotype CD4 T cellsPD-1high memory CD4 T cells are pathogenic in autoimmune disease; here they show their expression of Egr2 is defective in rheumatoid arthritis and Egr2 & 3 control their inflammation and homeostasis.
Attenuation of cGAS/STING activity during mitosisTo limit deleterious interferon responses with each cell division and open mitosis, cGAS/STING activities are shown to be dampened-with Golgi vesiculation preventing activation of STING.
EBV renders B cells susceptible to HIV-1 in humanized miceA proportion of EBV+ B cells are infectible by CXCR4-tropic HIV-1 in vitro and in vivo, and these HIV-infected B cells can transmit infection to previously virus-naïve humanized mice.
Multiple sclerosis risk variants regulate gene expression in innate and adaptive immune cellsThis comprehensive study identifies multiple sclerosis risk expression quantitative trait loci in purified immune cell types.
Tradeoff between metabolic i-proteasome addiction and immune evasion in triple-negative breast cancerEngaging the immunoproteasome helps maintain proteostasis during TNBC development, but ultimately leads to increased immune visibility and favorable prognosis. Assessing i-proteasome expression could augment the prognostic and/or predictive value of TILs assessment in diagnostic practice.
MAPK pathway mutations in head and neck cancer affect immune microenvironments and ErbB3 signalingMAPK mutations favor HNSCC survival, revealing the broad clinical utility of MAPK pathway mutations in prognosis and potentially in precision immunotherapy.
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMDCaspase-1 activation in GSDMD-deficient cells induces a rapid form of caspase-3–dependent secondary necrosis that is licenced by caspase-1–induced Bid cleavage and the release of mitochondrial SMAC.