Proposed activating mutations in Parkin (conserved in rat and human Parkin).
| Mutation | Domain | Reference(s) |
|---|---|---|
| R33Q | UBL | Chaugule et al (2011) |
| Y143D | RING0 | This article |
| Y143E | RING0 | This article |
| F146A | RING0 | Trempe et al (2013); Ordureau et al (2014); Tang et al (2017); Yi et al (2019) |
| W183Y | RING0 | This article |
| F208Y | RING0 | This article |
| H227N (human only) | RING1 | Kumar et al (2015) |
| H/N227A (human/rat) | RING1 | This article |
| L266K | RING1 | Sauvé et al (2015) |
| L266R | RING1 | This article |
| N273K | RING1 | Sauvé et al (2015); Tang et al (2017) |
| E300A | RING1 | Kumar et al (2015) |
| E300Q | RING1 | Kumar et al (2015) |
| E370A | IBR | This article |
| V393D | REP | This article |
| V393K | REP | This article |
| A397D | REP | This article |
| A397K | REP | This article |
| A398T | REP | Periquet et al (2003) |
| A398D | REP | This article |
| A398K | REP | This article |
| A401D | REP | This article |
| A401K | REP | This article |
| W403A | REP | Trempe et al (2013); Ordureau et al (2014); Sauvé et al (2015); Tang et al (2017); Yi et al (2019) |
| W403F | REP | This article |
| W462A | RING2 | This article |
| W462F | RING2 | This article |
| W462Y | RING2 | This article |
| F463Y | RING2 | Riley et al (2013) |
| D464A | RING2 | This article |
| D464K | RING2 | This article |