Table 4.

Comparison of polygenic risk score–continuous shrinkage (PRS-CS) and PRS.jl performance for binary traits.

Nagelkerke R2Area under the curve10% odds ratioNumber of subjects
PRS-CSPRS.jlPRS-CSPRS.jlPRS-CSPRS.jlCasesControls
Asthma0.0176 (<0.0001)0.0176 (<0.0001)0.560 (<0.0001)0.560 (0.0002)1.54 (0.02)1.54 (0.02)8,21064,618
Coronary artery disease0.3212 (0.0001)0.3214 (0.0001)0.552 (0.0004)0.552 (0.0005)1.71 (0.02)1.73 (0.01)16,80756,021
Type 2 diabetes mellitus0.1715 (<0.0001)0.1716 (<0.0001)0.626 (0.0001)0.626 (0.0001)2.75 (0.017)2.77 (0.008)13,68859,140
  • All data is presented as mean (SD).