Table 3.

Comparison of polygenic risk score–continuous shrinkage (PRS-CS) and PRS.jl performance for quantitative traits using, as covariates, age, sex, and PCs 1–10.

R2
PRS-CSPRS.jlNumber of subjects
Body mass index0.1141(<0.0001)0.1141 (<0.0001)60,584
Cholesterol0.1089 (0.0002)0.1088 (0.0002)34,347
eGFR0.4921 (<0.0001)0.4922 (<0.0001)34,797
High-density lipoprotein0.2326 (<0.0001)0.2326 (<0.0001)33,338
Low-density lipoprotein0.0835 (<0.0001)0.0835 (0.0001)32,061
Triglycerides0.0657 (<0.0001)0.0657 (<0.0001)34,531
  • All data is presented as mean (SD).