Table 1.

Npc1m1N/m1N mice treated with adeno-associated virus-PHP.B show allelic variance at the Ly6a locus that correlates with lifespan and copy number per cell.

SNP genotyping at Ly6a locusCopy number per cell
Age, wkars32279213brs213983347cCerebrumCerebellumLiver
9G/GC/C0.02290.0323.1
9A/GT/C0.6780.89912.7
9A/GT/C1.321.765.68
9A/GT/C0.8192.8615.2
11.1G/GC/C0.0270.04739.8
11.1G/GC/C0.02860.0326.8
34.9A/GT/C0.7990.5584.55
23.3A/GT/C0.2780.3291.28
33.4A/GT/CNDNDND
29.7A/GT/CNDNDND
45.4A/AT/T3.664.061.19
66.1A/AT/T3.752.560.82
52.9A/AT/T7.24.671
  • a 9-wk-old mice were deliberately euthanized at this age; all other ages reflect end stage of disease.

  • b G is the restrictive allele at rs32279213 (encoding p.G63) and A is the permissive allele (encoding p.D63).

  • c C is the restrictive allele at rs213983347 (encoding p.A106) and T is the permissive allele (encoding p.V106).

  • ND, not determined.