Npc1m1N/m1N mice treated with adeno-associated virus-PHP.B show allelic variance at the Ly6a locus that correlates with lifespan and copy number per cell.
| SNP genotyping at Ly6a locus | Copy number per cell | ||||
|---|---|---|---|---|---|
| Age, wka | rs32279213b | rs213983347c | Cerebrum | Cerebellum | Liver |
| 9 | G/G | C/C | 0.0229 | 0.032 | 3.1 |
| 9 | A/G | T/C | 0.678 | 0.899 | 12.7 |
| 9 | A/G | T/C | 1.32 | 1.76 | 5.68 |
| 9 | A/G | T/C | 0.819 | 2.86 | 15.2 |
| 11.1 | G/G | C/C | 0.027 | 0.047 | 39.8 |
| 11.1 | G/G | C/C | 0.0286 | 0.03 | 26.8 |
| 34.9 | A/G | T/C | 0.799 | 0.558 | 4.55 |
| 23.3 | A/G | T/C | 0.278 | 0.329 | 1.28 |
| 33.4 | A/G | T/C | ND | ND | ND |
| 29.7 | A/G | T/C | ND | ND | ND |
| 45.4 | A/A | T/T | 3.66 | 4.06 | 1.19 |
| 66.1 | A/A | T/T | 3.75 | 2.56 | 0.82 |
| 52.9 | A/A | T/T | 7.2 | 4.67 | 1 |
↵a 9-wk-old mice were deliberately euthanized at this age; all other ages reflect end stage of disease.
↵b G is the restrictive allele at rs32279213 (encoding p.G63) and A is the permissive allele (encoding p.D63).
↵c C is the restrictive allele at rs213983347 (encoding p.A106) and T is the permissive allele (encoding p.V106).
ND, not determined.