Table 1.

Expression profile of connector enhancer of kinase suppressor of Ras1 (CNKSR1) in human HER2-positive breast cancer tissues.

CNKSR1 low (n = 4)CNKSR1 high (n = 16)
AgeAverage67.75 (range 58–88)61.50 (range 36–90)
Level of invasionT10/8 (0%)8/8 (100%)
T24/9 (44%)5/9 (56%)
T30/1 (0%)1/1 (100%)
T40/2 (0%)2/2 (100%)
Lymph node metastasisN02/10 (20%)8/10 (80%)
N11/3 (33%)2/3 (67%)
N21/3 (33%)2/3 (67%)
N30/4 (0%)4/4 (100%)
StageI0/7 (0%)7/7 (100%)
II3/5 (60%)2/5 (40%)
III1/8 (12.5%)7/8 (87.5%)
Distant metastasisAbsent4/15 (26.7%)11/15 (73.3%)
Present0/5 (0%)5/5 (100%)
Ki-67Average49.75 (range 20–74)55.75 (range 30–90)
  • Total 20 of human HER2-positive breast cancer tissues were subjected to immunohistochemistry for CNKSR1. The number of human breast cancer tissues with CNKSR1-positive or CNKSR1-negative was counted. Breast cancer cells were defined as CNKSR1-positive when the signals for the CNKSR1-DAB staining were positive above the threshold 10 after subtraction.