Urine electrolytes/creatinine ratio in salt-sensitive rats during chronic opioid treatment within 14 d on HS.
| NS | NS | |
|---|---|---|
| Potassium | 8.5 ± 2 | 15 ± 2 |
| Sodium | 33 ± 5 | 23 ± 2 |
| Calcium | 0.24 ± 0.04 | 0.26 ± 0.03 |
| Chloride | 44 ± 8 | 32 ± 3 |
| 7DHS+Vehicle | 7DHS+BRL | |
| Potassium | 19 ± 3 | 16 ± 1 |
| Sodium | 437 ± 41 | 327 ± 17* |
| Calcium | 3.2 ± 0.5 | 2.9 ± 0.2 |
| Chloride | 402 ± 34 | 310 ± 15* |
| 14DHS+Vehicle | 14DHS+BRL | |
| Potassium | 19 ± 1 | 15 ± 1* |
| Sodium | 372 ± 30 | 255 ± 9* |
| Calcium | 2.9 ± 0.2 | 2.1 ± 0.1* |
| Chloride | 323 ± 24 | 241 ± 9* |
κ-OR agonist treated rats (1.5 mg/kg BRL 52537). NS (0.4% NaCl); 7DHS, 14DHS – 7 d and 14 d on HS (8% NaCl), respectively (n ≥ 5 rat per group; t test *P < 0.05, BRL- versus vehicle-treated rats on the same day of treatment).