Table 1.

Blood electrolytes analysis of salt-sensitive rats during chronic experiment with or without treatment with the opioids within 14 d on HS.

NSNS
Potassium3.2 ± 0.13.4 ± 0.1
Sodium143.8 ± 0.4141.4 ± 0.4
Calcium1.35 ± 0.011.32 ± 0.01
Chloride113 ± 4106 ± 2
7DHS+Vehicle7DHS+BRL
Potassium3.2 ± 0.13.1 ± 0.2
Sodium146 ± 1150 ± 2*
Calcium1.38 ± 0.011.30 ± 0.02
Chloride104 ± 1110 ± 2*
14DHS+Vehicle14DHS+BRL
Potassium3.1 ± 0.13.0 ± 0.1
Sodium143.3 ± 0.5146.7 ± 1.6
Calcium1.36 ± 0.011.23 ± 0.04*
Chloride101 ± 1106 ± 2
  • κ-OR agonist treated rats (1.5 mg/kg BRL 52537). NS (0.4% NaCl); 7DHS, 14DHS, 7 d and 14 d on HS (8% NaCl), respectively (n ≥ 5 rat per group; t test *P < 0.05, BRL- versus vehicle-treated rats on the same day of treatment).