Table 2.

Associations of histidine-rich glycoprotein profiles to various traits in set 3.

TraitHPA045005Bsi0137
EstimateaP-valueEstimateaP-value
Aging
 Age0.0101.53 × 10−60.00170.44
 Mortality risk1.256.45 × 10−51.030.59
Genetic/protein variants
 rs9898 (Pro204Ser)0.152.35 × 10−97−0.231.85 × 10−177
 rs1042464 (Asn493Ile)0.101.9 × 10−44−0.33<1 × 10−300
Clinical trait
 APOA1−0.269.47 × 10−6−0.010.76
 APOB−0.238.46 × 10−40.306.81 × 10−10
 C-reactive protein0.0127.33 × 10−50.00030.88
 Glucose−0.0280.0610.0130.21
 Hb−0.0086.45 × 10−90.00040.68
 HbA1C−0.0470.0700.0300.092
 High density lipoprotein−0.0350.41−0.1205.65 × 10−5
 Low density lipoprotein−0.0441.53 × 10−20.0711.90 × 10−8
 TC−0.0601.37 × 10−40.0604.92 × 10−8
 TG−0.0862.73 × 10−50.0742.36 × 10−7
  • a The estimates from selected models for individual associations. For clinical traits, the values are the estimated slope from linear regression models with adjustment for age and the top single-nucleotide polymorphism (rs9898 for HPA045005 and rs1042464 for BSI0137). Linear models were also used for age and genetic/protein variants, whereas Cox models for mortality risk (more details in the Materials and Methods section). For the trait, hazard ratios are presented in the column.

  • The two distinct histidin-rich glycoprotein profiles were compared with respect to the association with various traits in set 3, which are 2,999 samples from the TwinGene cohort (Lichtenstein et al, 2002; Magnusson et al, 2013).