Description of mouse models of pancreatic ductal adenocarcinoma (PDAC) used, including genotype, number of mice in each group, onset of PanINs (or intraductal papillary mucinous neoplasia [IPMN] for KSC) and PDAC, and percentage of remnant islets in mice with PanINs only or both PanINs and PDAC. None: no remnant islets, PanIN or PDAC lesions were found. N/P: mice did not show PanIN only. T/A: PDAC was analyzed when the mice were euthanized.
| Mice genotype | Onset PanIN only (mo) | Onset PDAC + PanIN (mo) | % Remnant islet (PanIN only) | % Remnant islet (PanIN + PDAC) |
|---|---|---|---|---|
| KC (n = 38) | 4–6 | 5–12 | 26% (5 mice) | 48% (19 mice) |
| KC+anti–TGF-β (n = 6) | 6 (T/A) | 6 (T/A) | 0% (2 mice) | 6% (4 mice) |
| KC−mTmG (n = 6) | None | None | None | None |
| KSC (n = 6) | 1–4 (IPMN) | 4–8 | N/P | 3% (6 mice) |
| Smad4KO (n = 3) | None | None | None | None |
| KTC (n = 6) | 1–2 | 1–2 | N/P | 0% (6 mice) |
| mTmG (n = 6) | None | None | None | None |
| β-LucTam (n = 6) | None | None | None | None |
| KβLucTam (n = 6) | None | None | None | None |
| HFD (n = 6) | None | None | None | None |
| Pancreatitis (n = 6) | None | None | None | None |