Table 3.

Most enriched pathways for genes down-regulated in the mammary gland of KO versus WT conventional animals.

GO biological process termCount%P-valueGenes
GO:0007155∼cell adhesion376.701.61E-8Ptprf, Fat2, Dscam, Perp, Fbln7, Cntnap2, Atp1b1, Cd24a, Ptk7, Epha1, Fn1, Pkp1, Lamc2, Col7a1, Lama1, Col13a1, Grhl2, Nrxn3, Itgb6, Fermt1, Spp1, Tenm2, Itgb4, Cd9, Celsr2, Cadm4, Cdh3, Cdh11, Col16a1, Col8a1, Cdh1, Itga8, Ephb1, Spon1, Nectin4, Flrt2, and Col14a1
GO:0042060∼wound healing162.891.84E-8Dsp, Arhgef19, Timp1, Tgfa, Msx2, Bnc1, Cdh3, Wnt5b, Tgfb3, Pak1, Plau, Ptk7, Erbb2, Fn1, Epb41 l4b, and Tgfb2
GO:0008285∼negative regulation of cell proliferation325.792.51E-8Ptprf, Timp2, Tfap2b, Irf6, Gata3, Sfrp1, Hspa1a, Sox9, Tfap2a, Runx1, Bnipl, Bmp7, Tgfb2, Vdr, Sfrp4, Scin, Cd9, Lif, Fgfr2, Msx2, Wnk2, Sfrp2, Frzb, Slit2, Tgfb3, Ptprz1, Plk5, Ovol2, Ror2, Nos1, Rerg, and Sox4
GO:0090090∼negative regulation of canonical Wnt signaling pathway142.532.33E-6Sox10, Nkd2, Cthrc1, Sfrp2, Wnt5b, Dkk3, Sfrp1, Frzb, Lrp4, Cdh1, Sox9, Ror2, Wnt4, and Sfrp4
GO:0007275∼multicellular organism development539.603.22E-6Shroom3, Sfrp1, Ngef, Lrp4, Enah, Tbx3, Dbn1, Sfrp4, Prrx2, Ephb3, Plekhb1, Lmx1b, Celsr2, Dkk3, Frzb, Slit2, Wnt2, Ovol2, Anpep, Wnt4, Ano1, Tmem100, Grem2, Elf3, Foxa1, Dact2, Fzd7, Wnt5b, Irx4, Kdf1, Fzd10, Mdfi, Bmp7, Mycbpap, Sema3d, Col13a1, Wnt7b, Vdr, Cited1, Smpd3, Msx2, Sfrp2, Itga8, Krt8, Eya2, Irx3, Trp63, Alx4, Ror2, Cxcl17, Dmbt1, Flrt2, and Islr2
GO:0061180∼mammary gland epithelium development61.084.66E-6Wnt2, Atp2c2, Prlr, Msx2, Wnt4, and Wnt7b
GO:0008284∼positive regulation of cell proliferation346.155.53E-6Tfap2b, Ccnd1, Ptn, Cxcr2, Sfrp1, Sox9, Tbx3, Pgr, Plau, Epcam, Epha1, Erbb2, Fn1, Areg, Lamc2, Tgfb2, Akr1c18, Wnt7b, Gas1, Lif, Tgfa, Timp1, Rab25, Fgfr2, Sfrp2, Wnt2, Id4, Pak1, Efemp1, Folr2, Osr2, Cldn7, Klf5, Sox4
GO:0030855∼epithelial cell differentiation111.998.26E-6Krt14, Muc1, Upk2, Trp63, Elf3, Aldoc, Vil1, Fgfr2, Bmp7, Bdh2, and Ehf
GO:0045669∼positive regulation of osteoblast differentiation111.999.46E-6Id4, Cd276, Trp63, Cthrc1, Msx2, Bmp7, Sfrp2, Wnt4, Ltf, Wnt7b, and Fbn2