Table 6.

Most enriched pathways for genes down-regulated in the pituitary of KO versus WT conventional animals.

GO biological process termCount%P-valueGenes
GO:0007156∼homophilic cell adhesion via plasma membrane adhesion molecules405.016.11E-23Pcdhga10, Pcdhga12, Pcdha11, Pcdhac2, Pcdha12, Pcdhb6, Pcdhb11, Pcdhgb1, Pcdhgc5, Pcdhb21, Pcdh10, Pcdhga9, Pcdhb8, Pcdha8, Pcdhga5, Pcdhga3, Pcdhgb8, Pcdhgb7, Pcdhgb5, Pcdhac1, Igsf9b, Pcdha9, Pcdhgb4, Pcdhgb2, Pcdhga8, Pcdhga6, Cdh12, Pcdhb19, Pcdhgb6, Cdh18, Pcdhb2, Pcdhb1, Pcdhb16, Pcdhga7, Sdk2, Cdh7, Pcdh11x, Pcdhga4, Pcdha5, and Pcdhga11
GO:0098742∼cell–cell adhesion via plasma membrane adhesion molecules425.269.39E-19Pcdhga10, Pcdhga12, Pcdha11, Pcdhac2, Pcdha12, Pcdhb6, Pcdhb11, Pcdhgb1, Pcdhgc5, Tenm1, Pcdhb21, Pcdh10, Pcdhga9, Pcdhb8, Pcdha8, Pcdhga5, Pcdhga3, Pcdhgb8, Pcdhgb7, Pcdhgb5, Pcdhac1, Igsf9b, Grid2, Pcdha9, Pcdhgb4, Pcdhgb2, Pcdhga8, Pcdhga6, Cdh12, Pcdhb19, Pcdhgb6, Cdh18, Pcdhb2, Pcdhb1, Pcdhb16, Pcdhga7, Sdk2, Cdh7, Pcdh11x, Pcdhga4, Pcdha5, and Pcdhga11
GO:0045653∼negative regulation of megakaryocyte differentiation91.122.35E-8Hist1h4a, Hist1h4c, Hist1h4i, Hist1h4f, Hist1h4j, Hist1h4d, Hist1h4h, Hist1h4k, and Hist2h4
GO:0055085∼transmembrane transport648.024.63E-7Slc36a4, G6pdx, Tspan13, Ucp1, Atp5g1, Lrrc8b, Slc14a1, Kcnv2, Utrn, Slc24a2, Atp7b, Slc17a9, Ryr2, Clcn5, Kcnk9, Cacna1c, Kcna6, Kcnd3, Slc1a7, Abcb1b, Sec61b, Gabrb2, Tmem245, Slc4a5, Asic2, Kcnip1, Kcna3, Nos1, Cacna1g, Crhbp, Slc30a7, Kcnb2, Trpc6, Htr1b, Gabra1, Slc8a1, Wnk3, Oprk1, Akap6, Mrs2, Slc30a8, Kcns2, Slc16a7, Gal, Kcnj6, Slc26a2, Atp6ap1l, Cacna1e, Kcnf1, Kcnh5, Tmem266, Aqp7, Slc5a8, Slc6a18, Nos1ap, Slc7a7, Slc5a7, Scnn1g, Reln, Klhl24, Oaz3, Slc8a3, Slc9a7, and Scn10a
GO:0006811∼ion transport789.771.28E-6Slc36a4, G6pdx, Ano4, Vip, Ank1, Nkain3, Tspan13, Mif, Ucp1, Atp5g1, Slc15a1, Lrrc8b, Utrn, Kcnv2, Cd84, Grin2a, Slc24a2, Atp7b, Slc17a9, Ryr2, Clcn5, Kcnk9, Cacna1c, Kcna6, Kcnd3, Slc1a7, Ano5, Gabrb2, Slc4a5, Asic2, Kcnip1, Kcna3, Nos1, Cacna1g, Crhbp, Slc30a7, Kcnb2, Trpc6, Htr1b, Gabra1, Slc8a1, Wnk3, Slc41a2, Oprk1, Mrs2, Akap6, Slc30a8, Kcns2, Slc16a7, Kcnj6, Gal, Slc26a2, Atp6ap1l, Pla2r1, Klhl3, Cacna1e, Kcnf1, Grid2, Kcnh5, Steap3, Tmem266, Aqp7, Slc5a8, Slc6a18, Nos1ap, Slc7a7, Slc5a7, Scnn1g, Grin2b, Reln, Best3, Klhl24, Nkain2, Chrna9, Slc8a3, Slc9a7, Cckar, and Scn10a
GO:0034220∼ion transmembrane transport486.011.65E-6Crhbp, Cacna1g, Kcnb2, Trpc6, Htr1b, G6pdx, Gabra1, Slc8a1, Tspan13, Wnk3, Oprk1, Atp5g1, Lrrc8b, Akap6, Kcnv2, Utrn, Slc24a2, Slc16a7, Kcns2, Atp7b, Ryr2, Gal, Kcnj6, Slc26a2, Clcn5, Atp6ap1l, Kcnk9, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Aqp7, Kcnd3, Nos1ap, Slc1a7, Scnn1g, Reln, Gabrb2, Klhl24, Asic2, Slc4a5, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, and Scn10a
GO:0030001∼metal ion transport506.261.22E-5Cacna1g, Slc30a7, Kcnb2, Trpc6, G6pdx, Htr1b, Vip, Slc8a1, Nkain3, Tspan13, Wnk3, Mif, Slc41a2, Oprk1, Akap6, Mrs2, Slc30a8, Utrn, Kcnv2, Grin2a, Cd84, Slc24a2, Kcns2, Atp7b, Kcnj6, Gal, Ryr2, Klhl3, Kcnk9, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Steap3, Kcna6, Slc5a8, Kcnd3, Nos1ap, Slc5a7, Scnn1g, Grin2b, Nkain2, Asic2, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, Cckar, and Scn10a
GO:0006812∼cation transport556.891.76E-5G6pdx, Vip, Ank1, Nkain3, Tspan13, Mif, Ucp1, Atp5g1, Kcnv2, Utrn, Cd84, Grin2a, Slc24a2, Atp7b, Ryr2, Kcnk9, Cacna1c, Kcna6, Kcnd3, Asic2, Kcnip1, Nos1, Kcna3, Cacna1g, Slc30a7, Kcnb2, Trpc6, Htr1b, Slc8a1, Slc41a2, Wnk3, Oprk1, Mrs2, Akap6, Slc30a8, Kcns2, Gal, Kcnj6, Klhl3, Atp6ap1l, Cacna1e, Kcnf1, Kcnh5, Steap3, Slc5a8, Nos1ap, Slc5a7, Scnn1g, Grin2b, Nkain2, Chrna9, Slc8a3, Slc9a7, Scn10a, and Cckar
GO:0043269∼regulation of ion transport405.011.97E-5Crhbp, Cacna1g, Kcnb2, Trpc6, G6pdx, Vip, Slc8a1, Nkain3, Tspan13, Wnk3, Mif, Oprk1, Slc15a1, Akap6, Utrn, Kcnv2, Cd84, Kcns2, Ryr2, Gal, Kcnj6, Pla2r1, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Grin2b, Reln, Best3, Nkain2, Klhl24, Asic2, Kcnip1, Kcna3, Nos1, Scn10a, Cckar
GO:0015672∼monovalent inorganic cation transport324.012.53E-5Kcnb2, Vip, Ank1, Slc8a1, Wnk3, Mif, Ucp1, Atp5g1, Oprk1, Akap6, Utrn, Kcnv2, Kcns2, Kcnj6, Gal, Klhl3, Atp6ap1l, Kcnk9, Kcnf1, Kcnh5, Kcna6, Slc5a8, Kcnd3, Slc5a7, Scnn1g, Asic2, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, and Scn10a
GO:0098660∼inorganic ion transmembrane transport384.762.74E-5Cacna1g, Kcnb2, Trpc6, Htr1b, G6pdx, Gabra1, Slc8a1, Wnk3, Atp5g1, Oprk1, Akap6, Utrn, Kcnv2, Slc24a2, Kcns2, Atp7b, Ryr2, Kcnj6, Gal, Slc26a2, Clcn5, Atp6ap1l, Kcnk9, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Scnn1g, Gabrb2, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, and Scn10a
GO:0007155∼cell adhesion8110.155.98E-5Pcdha11, Hist1h3e, Il2ra, Lamb3, Lpp, Itga1, Crisp2, Pcdhb11, Cntnap5c, Pcdhgc5, Utrn, Cd84, Tenm1, Pcdhb21, Pcdhga9, Tnr, Pcdha8, Pcdhga3, Nrxn3, Pcdhgb5, Igsf9b, Pcdha9, Pcdhgb4, Adam12, Cyfip2, Pkhd1, Hapln4, Pcdhb2, Edil3, Pcdhb16, Prkdc, Pcdhga7, Cdh7, Pcdh11x, Snai2, Agr2, Pcdhga4, Stat5a, Pcdhga10, Pcdhga12, Ncam2, Pcdhac2, Pcdha12, Pcdhb6, Omg, Pcdhgb1, Plet1, Scgb1a1, Omd, Cgref1, Crebbp, Pcdh10, Itgb8, Pcdhb8, Rps26, Pcdhga5, Pcdhgb8, Pcdhgb7, Sned1, Pcdhac1, Grid2, Gpam, Pcdhgb2, Pcdhga8, Epha5, Cntnap5b, Pcdhb19, Cdh12, Pcdhgb6, Pcdhga6, Cdh18, Hapln1, Pcdhb1, Tcam1, Reln, Sdk2, Phldb2, Flrt1, Pcdha5, S100a10, and Pcdhga11
GO:0034762∼regulation of transmembrane transport303.756.62E-5Crhbp, Kcnb2, Trpc6, G6pdx, Slc8a1, Tspan13, Wnk3, Oprk1, Akap6, Utrn, Kcnv2, Kcns2, Kcnj6, Gal, Ryr2, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Reln, Klhl24, Asic2, Oaz3, Kcnip1, Nos1, Kcna3, and Scn10a
GO:0098655∼cation transmembrane transport364.517.31E-5Cacna1g, Kcnb2, Trpc6, Htr1b, G6pdx, Slc8a1, Tspan13, Wnk3, Atp5g1, Oprk1, Akap6, Utrn, Kcnv2, Slc24a2, Kcns2, Atp7b, Ryr2, Kcnj6, Gal, Atp6ap1l, Kcnk9, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Scnn1g, Asic2, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, and Scn10a
GO:0022610∼biological adhesion8110.157.56E-5Pcdha11, Hist1h3e, Il2ra, Lamb3, Lpp, Itga1, Crisp2, Pcdhb11, Cntnap5c, Pcdhgc5, Utrn, Cd84, Tenm1, Pcdhb21, Pcdhga9, Tnr, Pcdha8, Pcdhga3, Nrxn3, Pcdhgb5, Igsf9b, Pcdha9, Pcdhgb4, Adam12, Cyfip2, Pkhd1, Hapln4, Pcdhb2, Edil3, Pcdhb16, Prkdc, Pcdhga7, Cdh7, Pcdh11x, Snai2, Agr2, Pcdhga4, Stat5a, Pcdhga10, Pcdhga12, Ncam2, Pcdhac2, Pcdha12, Pcdhb6, Omg, Pcdhgb1, Plet1, Scgb1a1, Omd, Cgref1, Crebbp, Pcdh10, Itgb8, Pcdhb8, Rps26, Pcdhga5, Pcdhgb8, Pcdhgb7, Sned1, Pcdhac1, Grid2, Gpam, Pcdhgb2, Pcdhga8, Epha5, Cntnap5b, Pcdhb19, Cdh12, Pcdhgb6, Pcdhga6, Cdh18, Hapln1, Pcdhb1, Tcam1, Reln, Sdk2, Phldb2, Flrt1, Pcdha5, S100a10, and Pcdhga11
GO:0034765∼regulation of ion transmembrane transport293.637.69E-5Crhbp, Kcnb2, Trpc6, G6pdx, Slc8a1, Tspan13, Wnk3, Oprk1, Akap6, Utrn, Kcnv2, Kcns2, Kcnj6, Gal, Ryr2, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Reln, Klhl24, Asic2, Kcnip1, Nos1, Kcna3, and Scn10a
GO:0098662∼inorganic cation transmembrane transport344.261.06E-4Cacna1g, Kcnb2, Trpc6, Htr1b, G6pdx, Slc8a1, Wnk3, Atp5g1, Oprk1, Akap6, Utrn, Kcnv2, Slc24a2, Kcns2, Atp7b, Ryr2, Kcnj6, Gal, Atp6ap1l, Kcnk9, Cacna1c, Cacna1e, Kcnf1, Kcnh5, Kcna6, Kcnd3, Nos1ap, Scnn1g, Slc8a3, Kcnip1, Kcna3, Nos1, Slc9a7, and Scn10a
GO:0007268∼chemical synaptic transmission374.631.35E-4Crhbp, Cacna1g, Ptpn5, Htr1b, Gabra1, Sytl5, Ssh1, Lrrtm2, Oprk1, Grin2a, Slc24a2, Cartpt, Cplx1, Syt6, Sstr2, Tnr, Rims4, Cacna1c, Nrxn3, Tmod2, Pclo, Igsf9b, Grid2, Gpr149, Slc5a7, Grin2b, Pcdhb16, Reln, Gabrb2, Chrna9, Gpr21, Adnp, Slc8a3, Slitrk5, Grm5, Nos1, and Retn
GO:0099536∼synaptic signaling374.631.35E-4Crhbp, Cacna1g, Ptpn5, Htr1b, Gabra1, Sytl5, Ssh1, Lrrtm2, Oprk1, Grin2a, Slc24a2, Cartpt, Cplx1, Syt6, Sstr2, Tnr, Rims4, Cacna1c, Nrxn3, Tmod2, Pclo, Igsf9b, Grid2, Gpr149, Slc5a7, Grin2b, Pcdhb16, Reln, Gabrb2, Chrna9, Gpr21, Adnp, Slc8a3, Slitrk5, Grm5, Nos1, and Retn
GO:0099537∼trans-synaptic signaling374.631.35E-4Crhbp, Cacna1g, Ptpn5, Htr1b, Gabra1, Sytl5, Ssh1, Lrrtm2, Oprk1, Grin2a, Slc24a2, Cartpt, Cplx1, Syt6, Sstr2, Tnr, Rims4, Cacna1c, Nrxn3, Tmod2, Pclo, Igsf9b, Grid2, Gpr149, Slc5a7, Grin2b, Pcdhb16, Reln, Gabrb2, Chrna9, Gpr21, Adnp, Slc8a3, Slitrk5, Grm5, Nos1, and Retn
GO:0098916∼anterograde trans-synaptic signaling374.631.35E-4Crhbp, Cacna1g, Ptpn5, Htr1b, Gabra1, Sytl5, Ssh1, Lrrtm2, Oprk1, Grin2a, Slc24a2, Cartpt, Cplx1, Syt6, Sstr2, Tnr, Rims4, Cacna1c, Nrxn3, Tmod2, Pclo, Igsf9b, Grid2, Gpr149, Slc5a7, Grin2b, Pcdhb16, Reln, Gabrb2, Chrna9, Gpr21, Adnp, Slc8a3, Slitrk5, Grm5, Nos1, and Retn
GO:0048511∼rhythmic process273.382.50E-4Prok2, Foxo3, Setx, Oprk1, Pgr, Grin2a, Cartpt, Crebbp, Nhlh2, Dmrta1, Prox1, Gpr149, Nrip1, Esr1, Arntl2, Atm, Prl, Grin2b, Prkdc, Tyms, Rbm4, Alb, Uba52, Adnp, Retn, Mmp19, and Stat5a
GO:0042698∼ovulation cycle141.753.42E-4Foxo3, Gpr149, Nrip1, Esr1, Atm, Prl, Oprk1, Pgr, Adnp, Nhlh2, Stat5a, Dmrta1, Mmp19, Retn
GO:0006813∼potassium ion transport182.253.85E-4Kcnf1, Kcnh5, Kcnb2, Kcna6, Vip, Kcnd3, Mif, Oprk1, Akap6, Kcnv2, Kcns2, Gal, Kcnj6, Kcnip1, Kcnk9, Nos1, Kcna3, and Slc9a7
GO:0065008∼regulation of biological quality14518.174.09E-4Slitrk3, Ano4, Foxo3, Vps13c, Vip, Frmpd4, Dock4, Lrrtm2, Mif, Fgd4, Ryr2, Tnr, Kcnk9, Cacna1c, Nrxn3, Pkhd1, Kcnd3, Esr1, Asic2, Agr2, Alb, Rbm4, Prlr, Slitrk5, Kcnip1, Nos1, Retn, 4932438A13Rik, Crhbp, Ptpn5, Heg1, Oit1, Trpc6, Htr1b, Plxna4, Sytl5, Stxbp5l, Dmxl1, Slc8a1, Ssh1, Wnk3, Tacr3, Myrip, Omg, Palm2, Tmsb10, Scgb1a1, Slc30a8, Gal, Nop10, Rims4, Cacna1e, Grid2, Kcnh5, Lnpep, Gpam, Pcsk6, Steap3, Sesn3, Gnat2, Kdelr3, Slc5a7, Rcor1, Scnn1g, Sorl1, Neb, Atp8b3, Usp13, Chrna9, Ptch1, Flrt1, Adnp, Grm5, Slc9a7, Cckar, Ppargc1b, Gckr, G6pdx, Il2ra, Ank1, Pycr1, Itga1, Cela2a, Grin2a, Brwd3, Slc24a2, Tenm1, Atp7b, Txndc2, Gng3, Vps13d, Tmod2, Cbl, Igsf9b, Ptpro, Lyst, Vkorc1, Myl4, Chst8, Hmbox1, Prl, Prkdc, Ar, Slc4a5, Tyms, Nr3c2, Gpr21, Mbd5, Stat5a, Cacna1g, Slc30a7, Tnks, Scd1, Pak3, Oprk1, Akap6, Col1a2, Cartpt, Cplx1, Syt6, Kcnj6, Slc26a2, Klhl3, Syndig1, Adgrb3, Pclo, Nme2, Malat1, Epha5, Cdkl5, F8, Fstl4, Nrip1, Uprt, Aqp7, Arhgap5, Rab38, Alms1, Atm, Ern1, Grin2b, Rab11fip2, Reln, Slc8a3, and Scn10a
GO:0007610∼behavior415.134.32E-4Crhbp, Ptpn5, Aff2, Htr1b, Vip, Mif, Tacr3, Oprk1, Hipk2, Grin2a, Pgr, Slc24a2, Cartpt, Gal, Nhlh2, Tnr, Cacna1c, Nrxn3, Dmrta1, Tmod2, Cacna1e, Adgrb3, Strn, Uba6, Grin2b, Prl, Ar, Reln, Adcy8, Unc79, Alb, Gpr21, Adnp, Mbd5, Slitrk5, Slc8a3, Pak7, Grm5, Nos1, Retn, and Cckar