Table 1.

Most enriched pathways for genes down-regulated in the mammary gland of KO versus WT specific and opportunistic pathogen-free animals.

GO biological process termCount%P-valueGenes
GO:0003012∼muscle system process1523.433.92E-12Cmya5, Mybpc2, Tmod1, Ttn, Tcap, Srl, Atp2a1, Myl1, Hrc, Ryr1, Casq1, Actn3, Tnni2, Cacna1s, and Myom1
GO:0006936∼muscle contraction1320.313.40E-11Mybpc2, Tmod1, Ttn, Tcap, Atp2a1, Myl1, Hrc, Ryr1, Casq1, Actn3, Tnni2, Cacna1s, and Myom1
GO:0006941∼striated muscle contraction914.061.60E-8Tnni2, Ttn, Tcap, Atp2a1, Myl1, Hrc, Casq1, Actn3, and Cacna1s
GO:0055002∼striated muscle cell development914.063.12E-8Actn3, Tmod1, Ttn, Cacna1s, Tcap, Ldb3, Ryr1, Casq1, and Neb
GO:0055001∼muscle cell development914.066.84E-8Actn3, Tmod1, Ttn, Cacna1s, Tcap, Ldb3, Ryr1, Casq1, and Neb
GO:0051146∼striated muscle cell differentiation1015.622.09E-7Actn3, Tmod1, Ttn, Cacna1s, Smyd1, Tcap, Ldb3, Ryr1, Casq1, and Neb
GO:0090257∼regulation of muscle system process914.062.37E-7Actn3, Tnni2, Cmya5, Ttn, Srl, Atp2a1, Ryr1, Hrc, and Casq1
GO:0061061∼muscle structure development1320.315.07E-7Jph1, Tmod1, Ttn, Smyd1, Tcap, Neb, Casq1, Ryr1, Actn3, Cacna1s, Mylpf, Jph2, and Ldb3
GO:0030239∼myofibril assembly69.378.79E-7Tmod1, Ttn, Tcap, Ldb3, Casq1, and Neb
GO:0007517∼muscle organ development1015.622.73E-6Actn3, Jph1, Ttn, Cacna1s, Jph2, Mylpf, Smyd1, Tcap, Ryr1, and Casq1
GO:0044057∼regulation of system process1117.182.91E-6Actn3, Tnni2, Cmya5, Ttn, Fgb, Cck, Srl, Atp2a1, Ryr1, Hrc, and Casq1
GO:0045214∼sarcomere organization57.814.02E-6Ttn, Tcap, Ldb3, Casq1, and Neb
GO:0042692∼muscle cell differentiation1015.624.63E-6Actn3, Tmod1, Ttn, Cacna1s, Smyd1, Tcap, Ldb3, Ryr1, Casq1, and Neb
GO:0003009∼skeletal muscle contraction57.815.63E-6Actn3, Tnni2, Tcap, Atp2a1, and Casq1