Correlation of behavioural findings in Iqsec2 KO mice and patients with loss-of-function mutations.
Test | Measure | Finding | Patient trait |
---|---|---|---|
Inverted Grid | Neuromuscular strength | Reduced | Dystonia/stereotypic hand movements |
Open Field | Exploration | Increased | Hyperactivity and psychiatric issues |
Anxiety (open spaces) | Increased | ||
Elevated zero maze | Fear response (height) | Reduced | Psychiatric issues |
Y-maze | Short term memory | Reduced | Intellectual disability |
Sociability | Social traits | Reduced | Autistic-like features |
Barnes Maze | Cognition | Reduced | Intellectual disability |