Table 2.

Correlation of behavioural findings in Iqsec2 KO mice and patients with loss-of-function mutations.

TestMeasureFindingPatient trait
Inverted GridNeuromuscular strengthReducedDystonia/stereotypic hand movements
Open FieldExplorationIncreasedHyperactivity and psychiatric issues
Anxiety (open spaces)Increased
Elevated zero mazeFear response (height)ReducedPsychiatric issues
Y-mazeShort term memoryReducedIntellectual disability
SociabilitySocial traitsReducedAutistic-like features
Barnes MazeCognitionReducedIntellectual disability