Correlation of behavioural findings in Iqsec2 KO mice and patients with loss-of-function mutations.
| Test | Measure | Finding | Patient trait |
|---|---|---|---|
| Inverted Grid | Neuromuscular strength | Reduced | Dystonia/stereotypic hand movements |
| Open Field | Exploration | Increased | Hyperactivity and psychiatric issues |
| Anxiety (open spaces) | Increased | ||
| Elevated zero maze | Fear response (height) | Reduced | Psychiatric issues |
| Y-maze | Short term memory | Reduced | Intellectual disability |
| Sociability | Social traits | Reduced | Autistic-like features |
| Barnes Maze | Cognition | Reduced | Intellectual disability |