Table 2.

False discovery corrected P-values obtained from regression of either Δ age (main method) or APOE ε4 with indicated disease or aging variables of interest.

Variable	Δ Age	APOE ε4
Variable	P-value	P-value
ΔGlobal cognition/yr	5.1 × 10⁻⁵^a	1.9 × 10⁻⁵^a
ΔEpisodic memory/yr	2.9 × 10⁻⁴^a	2.5 × 10⁻⁶^a
ΔVisual-spatial ability/yr	0.003^a	0.02^a
ΔPerceptual speed/yr	8.7 × 10⁻⁵^a	0.02^a
ΔSemantic memory/yr	5.1 × 10⁻⁵^a	1.6 × 10⁻⁵^a
ΔWorking memory/yr	0.03^a	0.006^a
Global cognition level	3.2 × 10⁻⁵^a	2.4 × 10⁻⁶^a
Episodic memory level	9 × 10⁻⁵^a	2.2 × 10⁻⁶^a
Dementia grade	0.006^a	7.6 × 10⁻⁵^a
AD clinical diagnosis	3.2 × 10⁻⁵^a	7.9 × 10⁻⁴^a
Mini mental examination score	0.0017^a	1.7 × 10⁻⁴^a
Depression score	0.69	0.85
General pathology	0.035^a	5.2 × 10⁻¹⁰^a
Plaque level	0.06	8.1 × 10⁻⁸^a
Tangles level	0.04^a	5.4 × 10⁻⁷^a
Amyloid level	0.15	5.4 × 10⁻⁷^a
Amyloid angiopathy	0.07^a	9.4 × 10⁻⁷^a
PD diagnosis	0.88	0.28
PD sign score	0.038^a	0.02^a
Gait	0.031^a	0.02^a
Bradykinesia	0.41	0.02^a
Rigidity	0.0059^a	0.035^a
Tremor	0.86	0.17
PD Pathology	0.006^a	0.88
Lewy body pathology	0.02^a	0.69
Stroke diagnosis	0.56	0.40
“Heart problem” history	0.17	0.90
Hypertension at baseline	0.003^b	0.67
Arteriolar sclerosis	0.75	0.84
Cerebral infarction gross	0.47	0.40
Cerebral infarction micro	0.33	0.58
Cancer history	0.91	0.95
Thyroid disease history	0.08	0.60
Smoking (lifetime pack-years)	0.75	0.46
APO ε4 alleles	0.035^a	0
Δ Age	0	0.035^a

↵a Indicate significantly increased risk with older Δ age or greater APOE ε4 alleles.
↵b Indicates the inverse relationship.