Table 1.

Estimated gBGC and iBGC for CO and NCO grouped into all donors (Ht+Ho), Ht, or Ho.

Rate Ratio-RR P-valueFxRcFx total (HSII)b
gBGC(strong/weak)
 CO
  Ht+Ho1.27 (1.17–1.38)<1 × 10−453.0%2.5 × 10−350.013%2.68 × 10−4
  Ht1.10 (0.98–1.23)0.1351.2%2.1 × 10−350.004%8.76 × 10−5
  Ho1.50 (1.33–1.69)<1 × 10−455.1%3.6 × 10−350.031%6.28 × 10−4
 NCO
  Ht+Ho0.93 (0.73–1.19)0.5849.0%7.1 × 10−449.999%−1.41 × 10−5
  Ht0.61 (0.42–0.86)<1 × 10−243.9%1.1 × 10−349.993%−1.35 × 10−4
  Ho1.54 (1.06–2.26)0.0255.4%5.0 × 10−450.003%5.38 × 10−5
iBGC(insertion/deletion)
 CO
  Ht 6/7 +9/19, Ho 6/71.17 (1.12–1.23)<1 × 10−452.0%2.1 × 10−350.004%8.27 × 10−5
  Ht+Ho 6/71.91 (1.60–2.28)<1 × 10−458.0%3.1 × 10−350.025%4.97 × 10−4
  Ht 6/7 + 9/191.17 (1.12–1.22)<1 × 10−452.0%2.9 × 10−350.006%1.14 × 10−4
  Ht 9/191.02 (1.00–1.04)0.0750.2%2.1 × 10−350.001%1.05 × 10−5
  Ht 6/71.95 (1.62–2.34)<1 × 10−458.3%2.9 × 10−350.024%4.80 × 10−4
  Ho 6/71.56 (0.80–3.03)0.2557.2%3.6 × 10−350.026%5.18 × 10−4
 NCO
  Ht 6/7 +9/19, Ho 6/70.59 (0.32–1.05)0.0843.4%1.4 × 10−349.991%−1.87 × 10−4
  Ht+Ho 6/71.54 (0.73–3.37)0.3055.4%7.2 × 10−450.004%7.36 × 10−5
  Ht 6/7 + 9/190.25 (0.08–0.63)0.00133.3%1.3 × 10−449.978%4.33 × 10−4
  Ht 6/72.0 (0.4–12.3)0.5158.6%1.3 × 10−350.011%2.23 × 10−4
  Ht 9/190.0 (0.00–0.19)<1 × 10−60.0%1.1 × 10−349.945%−1.10 × 10−3
  Ho 6/71.4 (0.58–3.52)0.5454.2%5.0 × 10−450.002%4.20 × 10−5
  • RR is the rate ratio of strong to weak alleles for gBGC or long versus short alleles for iBGC and approximates the value of one when alleles are equally transmitted; P is the significance of the RR; FxR is the percentage of recombinants with a biased transmission estimated as √RR/(1+ √RR), where 50% represents equal transmission; and c is the number recombinant products per amplifiable sperm genomes (see Table S2). Note that we used 2*CO, because two crossovers result per meiosis, yet we only measured one type (RI or RII) and 1*NCO, because only one NCO results in a meiotic division (Allers & Lichten, 2001); Fx total is the transmission bias in all sperm estimated as the sum of the proportion of non-recombinants and proportion of FxR (calculated as: 0.5*(1−FxR)+c*FxR); b is the selection coefficient estimated as (2*Fx total)−1.