Table 1.

AIC values for input search.

Model no.SubstrateProductAICAICcBIC
Single stress input
IIPI3KPI3K_p8,7888,8449,126
Second stress input in addition to PI3K
1AktAkt_pS4731,1271,1851,469
2Akt_pT308Akt_pT308_pS4731,5351,5931,877
3PDK1_cytPDK1_mem8,5958,6538,937
4AktAkt_pT3088,5978,6558,939
5TSC2TSC2_pT14628,5998,6578,941
6PRAS40PRAS40_pT2468,6238,6818,965
7PRAS40PRAS40_pS1838,6638,7219,005
8p70_S6Kp70_S6K_pT3898,6678,7249,009
9PRAS40_pS183PRAS40_pT246_pS1838,7048,7619,045
10p70_S6Kp70_S6K_pT2298,7068,7639,048
11IR_betaIR_beta_pY11468,7338,7919,075
12IRS1IRS1_loc_pS6368,7348,7919,076
13IRS1IRS1_loc8,7388,7959,080
144EBP14EBP1_pT37_468,7628,8209,104
15PRAS40_pS183PRAS408,7638,8219,105
16p70_S6K_pT229p70_S6K_pT229_pT3898,7688,8269,110
17p70_S6K_pT389p70_S6K_pT229_pT3898,7768,8349,118
18Akt_pT308_pS473Akt_pT3088,7778,8359,119
19Akt_pT308_pS473Akt_pS4738,7818,8399,123
20PRAS40_pT246PRAS40_pT246_pS1838,7818,8399,123
21IRS1_locIRS1_loc_pS6368,7818,8399,123
22TSC2_pT1462TSC28,7818,8399,123
23PI3K_pPI3K8,7818,8399,123
24PDK1_memPDK1_cyt8,7818,8399,123
25p70_S6K_pT229p70_S6K8,7818,8399,123
26IR_beta_pY1146IR_beta8,7828,8409,124
27Akt_pS473Akt_pT308_pS4738,7838,8419,125
28PRAS40_pT246PRAS408,7888,8469,130
29PRAS40_pT246_pS183PRAS40_pS1838,7888,8469,130
304EBP1_pT37_464EBP18,7908,8489,132
31PRAS40_pT246_pS183PRAS40_pT2468,7908,8489,132
32p70_S6K_pT229_pT389p70_S6K_pT3898,7918,8499,133
33Akt_pS473Akt8,7918,8499,133
34Akt_pT308Akt8,7978,8559,139
35IRS1_loc_pS636IRS18,7998,8579,141
36p70_S6K_pT389p70_S6K8,7998,8579,141
37p70_S6K_pT229_pT389p70_S6K_pT2298,8038,8619,145
  • Model fitting quality determined by computing the AIC, the AIC corrected for small sample sizes (AICc), or the BIC. Upper part: fitting quality of model II. Lower part: fitting quality of model II with an additional stress input. Each value is computed by running Latin hypercube sampling 500 times with the indicated stress inputs.