Table 1.

Pathway-enrichment analysis.

CountP
Enrichment cluster 1 (score, 3.64)
 Lipid biosynthesis145.1 × 10−8
 Lipid metabolic process208.4 × 10−6
 Lipid metabolism188.9 × 10−6
 Fatty acid desaturase, type 159.4 × 10−6
 Unsaturated fatty acid biosynthetic process53.3 × 10−5
 Stearoyl-CoA 9-desaturase activity43.7 × 10−5
 Fatty acid biosynthesis73.8 × 10−5
 Fatty acid biosynthetic process84.7 × 10−5
 Biosynthesis of unsaturated fatty acid65.1 × 10−5
 Fatty acid metabolism91.0 × 10−4
 Long-chain fatty acid biosynthetic process41.7 × 10−4
 PPAR signaling pathway82.3 × 10−4
 Palmitoyl-CoA 9-desaturase activity39.2 × 10−4
 Monosaturated fatty acid biosynthetic process39.8 × 10−4
Enrichment cluster 2 (score, 3.42)
 Nucleosome131.1 × 10−8
 Negative regulation of cell proliferation141.5 × 10−3
 Ubl conjugation312.8 × 10−3
Enrichment cluster 3 (score, 3.31)
 ER341.2 × 10−4
Enrichment cluster 4 (score, 3.01)
 Sterol biosynthetic process62.2 × 10−5
 Cholesterol biosynthetic process65.2 × 10−5
 Cholesterol biosynthesis57.5 × 10−5
 Steroid biosynthesis67.5 × 10−5
 Cholesterol metabolism64.5 × 10−4
 Sterol metabolism67.8 × 10−4
 Cholesterol metabolic process71.0 × 10−3
 Steroid biosynthetic process61.2 × 10−3
 Steroid metabolism61.7 × 10−3
Enrichment cluster 4 (score, 2.26)
 Oxidereductase195.3 × 10−4
 Oxidereductase activity196.0 × 10−4
 Oxidation-reduction process193.0 × 10−3
 NADP71.7 × 10−3
  • Pathway-enrichment analysis of gene expression with down-regulation in CD4+ T cells stimulated with anti-CD3/28 plus cGAMP for 24 h as compared with those stimulated with anti-CD3/28 alone. Data were analyzed with DAVID Bioinformatics Resources 6.8 and represent one experiment.