Table 1.

Clinical EAE signs in HDAC11 WT and HDAC11 KO mice after immunization with MOG35–55.

HDAC11 WTHDAC11 KO
Number of animals (n)1010
Percent incidence100%100%
Day of onset13.2 ± 0.413.3 ± 0.5
Clinical score3.3 ± 0.72.4 ± 0.5
Peak disease severity4.1 ± 0.92.1 ± 1.0
  • Disease onset is defined by the second consecutive day in which the animals showed a clinical score of at least 0.5. Results for day of onset, clinical score, and peak of disease severity are shown as mean ± SEM (P < 0.05; Mann–Whitney U test).