Table 4.

Activity of diazaborines against M. tuberculosis drug-resistant clinical isolates.

StrainResistanceMIC (μg/ml)
AN12855MOXIPA-284RIFINH
H37RvNone (WT)0.130.130.25<0.06<0.06
M70FQ, STR, INH, RIF, and PZA0.2510.25>16>16
M28FQ, INH, RIF, EMB, and PZA0.252<0.06>16>16
TN5904STR, INH, RIF, and PZA0.130.130.13>161
  • FQ, fluoroquinolone; STR, streptomycin; RIF, rifampicin; PZA, pyrazinamide; MOXI, moxifloxacin.