Table 5.

Thermodynamic analysis of interactions between compounds and M. tuberculosis InhA.

CompoundCofactorKd (nM)∆H (cal/mol)∆S (cal/mol/deg)N
AN12855None77 ± 31−17,740 ± 607−270.58 ± 0.014
AN12908NAD+847 ± 318−25,010 ± 1,496−560.49 ± 0.022
  • ΔH, change in enthalpy; ΔS, change in entropy; N, stoichiometry of binding.