Profile of diazaborine-resistant mutants.
| Strain | InhA SNP | Solid media MIC (μM) | Liquid media IC90 (μM) | ||
|---|---|---|---|---|---|
| AN3438 | AN6534 | AN12855 | INH | ||
| H37Rv-LP | WT | 12.5 | 44 | 0.05 | 0.3 |
| LP-AN3438-RM1 | I16T | 25 | 34 | 0.4 | |
| LP-AN3438-RM2 | P151S | 50 | >200 | 0.1 | |
| LP-AN3438-RM3 | D148G | 50 | >200 | 0.1 | |
| LP-AN3438-RM4 | R195Q | 100 | >200 | 0.4 | |
| LP-AN3438-RM5 | E219A | 100 | 26 | 0.1 | |
| LP-AN3438-RM6 | I202T | 25 | 160 | 0.2 | |
| LP-AN12855-RM1 | R195L | 3.0 | 0.4 | ||
| LP-AN12855-RM2 | D148G | 0.8 | 0.3 | ||
| LP-AN12855-RM3 | E219G | 4.6 | 0.1 | ||