Table 3.

Resistance of M. tuberculosis inhA promoter and coding sequence mutants against the cofactor-independent diazaborine AN12855.

StrainSNPsaLiquid IC90 (fold shift versus WT)b
fabG1inhA promoter (nt)InhA (Am Ac)AN12855INHc
H37Rv0.06 μM0.1 μM
LP-0532543-RM18S19W
LP-0532543-RM28I21M
LP-0532543-RM34I21V
LP-0532543-RM13F41L
LP-0532543-RM19I47L
LP-0532543-RM1S94A
LP-0532543-RM6M103T
LP-0532543-RM2D148E
LP-0532543-RM4M161L
LP-0571426-RM24I194T
LP-0532543-RM41R195G16×
LP-0532543-RM9I202F
LP-0532543-RM7G205A
LP-0532543-RM11G205S
LP-0532543-RM3A206E
LP-0532543-RM14G212D
LP-0532543-RM16I215S15×
LP-0532543-RM37L269R
LP-0532543-RM30c-15t
LP-0532543-RM314c-15tI47M
LP-0532543-RM301c-15tN159K
LP-0532543-RM311c-15tM161V84×
LP-0532543-RM304c-15tT162M26×
LP-0532543-RM318c-15tM199L10×
LP-0532543-RM313c-15tG205D13×
LP-0532543-RM320c-15tG208D16×
  • a No change in sequence from WT H37Rv.

  • b Liquid IC90 values WT results are presented as μM, whereas RM IC90 are presented as the fold change compared with WT.

  • c INH values are from McNeil et al (2017).