Table 3.

Resistance of M. tuberculosis inhA promoter and coding sequence mutants against the cofactor-independent diazaborine AN12855.

StrainSNPsaLiquid IC90 (fold shift versus WT)b
fabG1inhA promoter (nt)InhA (Am Ac)AN12855INHc
H37Rv——0.06 μM0.1 μM
LP-0532543-RM18—S19W1×1×
LP-0532543-RM28—I21M1×1×
LP-0532543-RM34—I21V1×2×
LP-0532543-RM13—F41L1×1×
LP-0532543-RM19—I47L3×1×
LP-0532543-RM1—S94A1×2×
LP-0532543-RM6—M103T2×1×
LP-0532543-RM2—D148E5×1×
LP-0532543-RM4—M161L4×1×
LP-0571426-RM24—I194T3×3×
LP-0532543-RM41—R195G16×2×
LP-0532543-RM9—I202F2×1×
LP-0532543-RM7—G205A2×1×
LP-0532543-RM11—G205S2×1×
LP-0532543-RM3—A206E2×1×
LP-0532543-RM14—G212D3×1×
LP-0532543-RM16—I215S15×1×
LP-0532543-RM37—L269R1×1×
LP-0532543-RM30c-15t—5×5×
LP-0532543-RM314c-15tI47M7×5×
LP-0532543-RM301c-15tN159K8×3×
LP-0532543-RM311c-15tM161V84×5×
LP-0532543-RM304c-15tT162M26×4×
LP-0532543-RM318c-15tM199L10×4×
LP-0532543-RM313c-15tG205D13×2×
LP-0532543-RM320c-15tG208D16×4×

  • ↵a No change in sequence from WT H37Rv.

  • ↵b Liquid IC90 values WT results are presented as μM, whereas RM IC90 are presented as the fold change compared with WT.

  • ↵c INH values are from McNeil et al (2017).