PT  - JOURNAL ARTICLE
AU  - Dalla Torre, Marco
AU  - Pittari, Daniele
AU  - Boletta, Alessandra
AU  - Cassina, Laura
AU  - Sitia, Roberto
AU  - Anelli, Tiziana
TI  - Mitochondria remodeling during endometrial stromal cell decidualization
AID  - 10.26508/lsa.202402627
DP  - 2024 Dec 01
TA  - Life Science Alliance
PG  - e202402627
VI  - 7
IP  - 12
4099  - https://www.life-science-alliance.org/content/7/12/e202402627.short
4100  - https://www.life-science-alliance.org/content/7/12/e202402627.full
SO  - Life Sci. Alliance2024 Dec 01; 7
AB  - Upon hormonal stimulation, uterine endometrial stromal cells undergo a dramatic morpho-functional metamorphosis that allows them to secrete large amounts of matrix proteins, cytokines, and growth factors. This step, known as decidualization, is crucial for embryo implantation. We previously demonstrated how the secretory pathway is remodelled during this process. Here we show that hormonal stimulation rapidly induces the expression of many mitochondrial genes, encoded in both the mitochondrial and the nuclear genomes. Altogether, the mitochondrial network quadruples its size and establishes more contacts with the ER. This new organization results in the increased respiratory capacity of decidualized cells. These findings reveal how achieving an efficient secretory phenotype requires a radical metabolic rewiring.The datasets presented in this study can be found in online repositories. The names of the repository/repositories and accession number(s) can be found below: GEO accession: GSE200200.