PT  - JOURNAL ARTICLE
AU  - Boston, Rebecca H
AU  - Guan, Rui
AU  - Kalmar, Lajos
AU  - Beier, Sina
AU  - Horner, Emily C
AU  - Beristain-Covarrubias, Nonantzin
AU  - Yam-Puc, Juan Carlos
AU  - Pereyra Gerber, Pehuén
AU  - Faria, Luisa
AU  - Kuroshchenkova, Anna
AU  - Lindell, Anna E
AU  - Blasche, Sonja
AU  - Correa-Noguera, Andrea
AU  - Elmer, Anne
AU  - Saunders, Caroline
AU  - Bermperi, Areti
AU  - Jose, Sherly
AU  - Kingston, Nathalie
AU  - ,
AU  - Grigoriadou, Sofia
AU  - Staples, Emily
AU  - Buckland, Matthew S
AU  - Lear, Sara
AU  - Matheson, Nicholas J
AU  - Benes, Vladimir
AU  - Parkinson, Christine
AU  - Thaventhiran, James ED
AU  - Patil, Kiran R
TI  - Stability of gut microbiome after COVID-19 vaccination in healthy and immuno-compromised individuals
AID  - 10.26508/lsa.202302529
DP  - 2024 Apr 01
TA  - Life Science Alliance
PG  - e202302529
VI  - 7
IP  - 4
4099  - https://www.life-science-alliance.org/content/7/4/e202302529.short
4100  - https://www.life-science-alliance.org/content/7/4/e202302529.full
SO  - Life Sci. Alliance2024 Apr 01; 7
AB  - Bidirectional interactions between the immune system and the gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer and autoimmunity, and efficacy of immunomodulatory therapies, have been linked to microbiome variation. Although COVID-19 infection has been shown to cause microbial dysbiosis, it remains understudied whether the inflammatory response associated with vaccination also impacts the microbiota. Here, we investigate the temporal impact of COVID-19 vaccination on the gut microbiome in healthy and immuno-compromised individuals; the latter included patients with primary immunodeficiency and cancer patients on immunomodulating therapies. We find that the gut microbiome remained remarkably stable post-vaccination irrespective of diverse immune status, vaccine response, and microbial composition spanned by the cohort. The stability is evident at all evaluated levels including diversity, phylum, species, and functional capacity. Our results indicate the resilience of the gut microbiome to host immune changes triggered by COVID-19 vaccination and suggest minimal, if any, impact on microbiome-mediated processes. These findings encourage vaccine acceptance, particularly when contrasted with the significant microbiome shifts observed during COVID-19 infection.