RT Journal Article
SR Electronic
T1 VDR is an essential regulator of hair follicle regression through the progression of cell death
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202302014
DO 10.26508/lsa.202302014
VO 6
IS 11
A1 Joko, Yudai
A1 Yamamoto, Yoko
A1 Kato, Shigeaki
A1 Takemoto, Tatsuya
A1 Abe, Masahiro
A1 Matsumoto, Toshio
A1 Fukumoto, Seiji
A1 Sawatsubashi, Shun
YR 2023
UL http://www.life-science-alliance.org/content/6/11/e202302014.abstract
AB Vitamin D receptor (VDR) is essential for hair follicle homeostasis as its deficiency induces hair loss, although the mechanism involved remains unknown. Our research shows that, in Vdr-knockout mice, the hair cycle is halted during the catagen stage, preceding alopecia. In addition, in Vdr-knockout hair follicles, epithelial strands that normally regress during the catagen phase persist as “surviving epithelial strands.” Single-cell RNA sequencing analysis suggests that these surviving epithelial strands are formed by cells in the lower part of the hair follicle. These findings emphasize the importance of the regression phase in hair follicle regeneration and establish VDR as a regulator of the catagen stage.