RT Journal Article
SR Electronic
T1 Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202301970
DO 10.26508/lsa.202301970
VO 6
IS 8
A1 Steffen Abay-Nørgaard
A1 Marta Cecylia Tapia
A1 Mandoh Zeijdner
A1 Jeonghwan Henry Kim
A1 Kyoung Jae Won
A1 Bo Porse
A1 Anna Elisabetta Salcini
YR 2023
UL https://www.life-science-alliance.org/content/6/8/e202301970.abstract
AB Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis.