PT  - JOURNAL ARTICLE
AU  - Steffen Abay-Nørgaard
AU  - Marta Cecylia Tapia
AU  - Mandoh Zeijdner
AU  - Jeonghwan Henry Kim
AU  - Kyoung Jae Won
AU  - Bo Porse
AU  - Anna Elisabetta Salcini
TI  - Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis
AID  - 10.26508/lsa.202301970
DP  - 2023 Aug 01
TA  - Life Science Alliance
PG  - e202301970
VI  - 6
IP  - 8
4099  - https://www.life-science-alliance.org/content/6/8/e202301970.short
4100  - https://www.life-science-alliance.org/content/6/8/e202301970.full
SO  - Life Sci. Alliance2023 Aug 01; 6
AB  - Epigenetic marks and associated traits can be transmitted for one or more generations, phenomena known respectively as inter- or transgenerational epigenetic inheritance. It remains unknown if genetically and conditionally induced aberrant epigenetic states can influence the development of the nervous system across generations. Here, we show, using Caenorhabditis elegans as a model system, that alteration of H3K4me3 levels in the parental generation, caused by genetic manipulation or changes in parental conditions, has, respectively, trans- and intergenerational effects on H3K4 methylome, transcriptome, and nervous system development. Thus, our study reveals the relevance of H3K4me3 transmission and maintenance in preventing long-lasting deleterious effects in nervous system homeostasis.