RT Journal Article
SR Electronic
T1 Mature B cells and mesenchymal stem cells control emergency myelopoiesis
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202301924
DO 10.26508/lsa.202301924
VO 6
IS 4
A1 Vivian Y Lim
A1 Xing Feng
A1 Runfeng Miao
A1 Sandra Zehentmeier
A1 Nathan Ewing-Crystal
A1 Moonyoung Lee
A1 Alexei V Tumanov
A1 Ji Eun Oh
A1 Akiko Iwasaki
A1 Andrew Wang
A1 Jungmin Choi
A1 João P Pereira
YR 2023
UL https://www.life-science-alliance.org/content/6/4/e202301924.abstract
AB Systemic inflammation halts lymphopoiesis and prioritizes myeloid cell production. How blood cell production switches from homeostasis to emergency myelopoiesis is incompletely understood. Here, we show that lymphotoxin-β receptor (LTβR) signaling in combination with TNF and IL-1 receptor signaling in bone marrow mesenchymal stem cells (MSCs) down-regulates Il7 expression to shut down lymphopoiesis during systemic inflammation. LTβR signaling in MSCs also promoted CCL2 production during systemic inflammation. Pharmacological or genetic blocking of LTβR signaling in MSCs partially enabled lymphopoiesis and reduced monocyte numbers in the spleen during systemic inflammation, which correlated with reduced survival during systemic bacterial and viral infections. Interestingly, lymphotoxin-α1β2 delivered by B-lineage cells, and specifically by mature B cells, contributed to promote Il7 down-regulation and reduce MSC lymphopoietic activity. Our studies revealed an unexpected role of LTβR signaling in MSCs and identified recirculating mature B cells as an important regulator of emergency myelopoiesis.