RT Journal Article
SR Electronic
T1 Disease- and sex-specific differences in patients with heart valve disease: a proteome study
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202201411
DO 10.26508/lsa.202201411
VO 6
IS 3
A1 Sarah Nordmeyer
A1 Milena Kraus
A1 Matthias Ziehm
A1 Marieluise Kirchner
A1 Marie Schafstedde
A1 Marcus Kelm
A1 Sylvia Niquet
A1 Mariet Mathew Stephen
A1 Istvan Baczko
A1 Christoph Knosalla
A1 Matthieu-P Schapranow
A1 Gunnar Dittmar
A1 Michael Gotthardt
A1 Martin Falcke
A1 Vera Regitz-Zagrosek
A1 Titus Kuehne
A1 Philipp Mertins
YR 2023
UL https://www.life-science-alliance.org/content/6/3/e202201411.abstract
AB Pressure overload in patients with aortic valve stenosis and volume overload in mitral valve regurgitation trigger specific forms of cardiac remodeling; however, little is known about similarities and differences in myocardial proteome regulation. We performed proteome profiling of 75 human left ventricular myocardial biopsies (aortic stenosis = 41, mitral regurgitation = 17, and controls = 17) using high-resolution tandem mass spectrometry next to clinical and hemodynamic parameter acquisition. In patients of both disease groups, proteins related to ECM and cytoskeleton were more abundant, whereas those related to energy metabolism and proteostasis were less abundant compared with controls. In addition, disease group–specific and sex-specific differences have been observed. Male patients with aortic stenosis showed more proteins related to fibrosis and less to energy metabolism, whereas female patients showed strong reduction in proteostasis-related proteins. Clinical imaging was in line with proteomic findings, showing elevation of fibrosis in both patient groups and sex differences. Disease- and sex-specific proteomic profiles provide insight into cardiac remodeling in patients with heart valve disease and might help improve the understanding of molecular mechanisms and the development of individualized treatment strategies.