PT  - JOURNAL ARTICLE
AU  - Hsu, Man Lun
AU  - Zouali, Moncef
TI  - Inflammasome is a central player in B cell development and homing
AID  - 10.26508/lsa.202201700
DP  - 2023 Feb 01
TA  - Life Science Alliance
PG  - e202201700
VI  - 6
IP  - 2
4099  - https://www.life-science-alliance.org/content/6/2/e202201700.short
4100  - https://www.life-science-alliance.org/content/6/2/e202201700.full
SO  - Life Sci. Alliance2023 Feb 01; 6
AB  - Whereas the role of the nucleotide-binding oligomerization domain, leucine-rich repeat and pyrin domain–containing protein (NLRP) 3 pathway in innate immunity has been extensively studied, little attention has been paid to its contribution to adaptive immunity. Studies in animal models and human subjects have shown the contribution of NLRP3 to the T cell compartment, and its role in B lymphocyte functions has been proposed. Here, we report that ablation of nlrp3 in mice led to altered B cell development in the bone marrow, and distorted expression of B cell subsets that play innate-like functions, that is, marginal zone B cells in the spleen and B-1a cells in the peritoneal cavity. Mechanistically, in the absence of NLRP3 expression, the transcription factor IRF4, previously found to interact with NLRP3 in the nucleus of lymphocytes, was up-regulated. NLRP3 ablation reduced the expression of the chemokine receptors CXCR4 and CCR7 in an IRF4-dependent manner, indicating that the presence of NLRP3 is critical for optimal expression of chemokine receptors on B cells. We conclude that activation of the NLRP3 inflammasome plays a role in B cell development, homing, and retention in lymphoid organs.