PT  - JOURNAL ARTICLE
AU  - Aala A Abulfaraj
AU  - Hajime Ohyanagi
AU  - Kosuke Goto
AU  - Katsuhiko Mineta
AU  - Takashi Gojobori
AU  - Heribert Hirt
AU  - Naganand Rayapuram
TI  - Comprehensive evolutionary analysis and nomenclature of plant G3BPs
AID  - 10.26508/lsa.202101328
DP  - 2022 Sep 01
TA  - Life Science Alliance
PG  - e202101328
VI  - 5
IP  - 9
4099  - https://www.life-science-alliance.org/content/5/9/e202101328.short
4100  - https://www.life-science-alliance.org/content/5/9/e202101328.full
SO  - Life Sci. Alliance2022 Sep 01; 5
AB  - Stress induces extensive reprogramming of mRNA metabolism, which includes the transcription and translation of stress-related genes and the formation of stress granules. RasGAP SH3 domain–binding proteins (G3BPs, also called Rasputins) form a highly conserved family of proteins found throughout eukaryotic evolution, which coordinate signal transduction and posttranscriptional gene regulation and play a key role in the formation of stress granules. G3BPs play a role in osmotic, oxidative, and biotic stress in mammals, and recent results revealed that they play similar functions in higher plants. Although simple eukaryotes such as yeast have only one G3BP gene, higher plants show a massive expansion of their G3BP genes into distinct subfamilies. However, because this family of genes has not been well-characterized in plants, functions that have evolved during this expansion remain unidentified. Therefore, we carried out a phylogenetic analysis of G3BPs in different eukaryotes, particularly focusing on the green lineage. On the basis of this evolutionary analysis of G3BPs in eukaryotes, we propose a uniform nomenclature for plant G3BPs that should help predict the evolutionary and functional diversification in this family.