RT Journal Article
SR Electronic
T1 Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202101344
DO 10.26508/lsa.202101344
VO 5
IS 8
A1 Nina Tanaskovic
A1 Mattia Dalsass
A1 Marco Filipuzzi
A1 Giorgia Ceccotti
A1 Alessandro Verrecchia
A1 Paola Nicoli
A1 Mirko Doni
A1 Daniela Olivero
A1 Diego Pasini
A1 Haruhiko Koseki
A1 Arianna Sabò
A1 Andrea Bisso
A1 Bruno Amati
YR 2022
UL https://www.life-science-alliance.org/content/5/8/e202101344.abstract
AB Max is an obligate dimerization partner for the Myc transcription factors and for several repressors, such as Mnt, Mxd1-4, and Mga, collectively thought to antagonize Myc function in transcription and oncogenesis. Mga, in particular, is part of the variant Polycomb group repressive complex PRC1.6. Here, we show that ablation of the distinct PRC1.6 subunit Pcgf6–but not Mga–accelerates Myc-induced lymphomagenesis in Eµ-myc transgenic mice. Unexpectedly, however, Pcgf6 loss shows no significant impact on transcriptional profiles, in neither pre-tumoral B-cells, nor lymphomas. Altogether, these data unravel an unforeseen, Mga- and PRC1.6-independent tumor suppressor activity of Pcgf6.