PT - JOURNAL ARTICLE AU - Nina Tanaskovic AU - Mattia Dalsass AU - Marco Filipuzzi AU - Giorgia Ceccotti AU - Alessandro Verrecchia AU - Paola Nicoli AU - Mirko Doni AU - Daniela Olivero AU - Diego Pasini AU - Haruhiko Koseki AU - Arianna Sabò AU - Andrea Bisso AU - Bruno Amati TI - Polycomb group ring finger protein 6 suppresses Myc-induced lymphomagenesis AID - 10.26508/lsa.202101344 DP - 2022 Aug 01 TA - Life Science Alliance PG - e202101344 VI - 5 IP - 8 4099 - https://www.life-science-alliance.org/content/5/8/e202101344.short 4100 - https://www.life-science-alliance.org/content/5/8/e202101344.full SO - Life Sci. Alliance2022 Aug 01; 5 AB - Max is an obligate dimerization partner for the Myc transcription factors and for several repressors, such as Mnt, Mxd1-4, and Mga, collectively thought to antagonize Myc function in transcription and oncogenesis. Mga, in particular, is part of the variant Polycomb group repressive complex PRC1.6. Here, we show that ablation of the distinct PRC1.6 subunit Pcgf6–but not Mga–accelerates Myc-induced lymphomagenesis in Eµ-myc transgenic mice. Unexpectedly, however, Pcgf6 loss shows no significant impact on transcriptional profiles, in neither pre-tumoral B-cells, nor lymphomas. Altogether, these data unravel an unforeseen, Mga- and PRC1.6-independent tumor suppressor activity of Pcgf6.