RT Journal Article
SR Electronic
T1 Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202101056
DO 10.26508/lsa.202101056
VO 4
IS 10
A1 Jennifer L Vella
A1 Aleksey Molodtsov
A1 Christina V Angeles
A1 Bruce R Branchini
A1 Mary Jo Turk
A1 Yina H Huang
YR 2021
UL https://www.life-science-alliance.org/content/4/10/e202101056.abstract
AB Tissue-resident memory (TRM) T cells are emerging as critical components of the immune response to cancer; yet, requirements for their ongoing function and maintenance remain unclear. APCs promote TRM cell differentiation and re-activation but have not been implicated in sustaining TRM cell responses. Here, we identified a novel role for dendritic cells in supporting TRM to melanoma. We showed that CD8 TRM cells remain in close proximity to dendritic cells in the skin. Depletion of CD11c+ cells results in rapid disaggregation and eventual loss of melanoma-specific TRM cells. In addition, we determined that TRM migration and/or persistence requires chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis. The interaction between CXCR6-expressing TRM cells and CXCL16-expressing APCs was found to be critical for sustaining TRM cell–mediated tumor protection. These findings substantially expand our knowledge of APC functions in TRM T-cell homeostasis and longevity.