RT Journal Article
SR Electronic
T1 A serum proteome signature to predict mortality in severe COVID-19 patients
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202101099
DO 10.26508/lsa.202101099
VO 4
IS 9
A1 Franziska Völlmy
A1 Henk van den Toorn
A1 Riccardo Zenezini Chiozzi
A1 Ottavio Zucchetti
A1 Alberto Papi
A1 Carlo Alberto Volta
A1 Luisa Marracino
A1 Francesco Vieceli Dalla Sega
A1 Francesca Fortini
A1 Vadim Demichev
A1 Pinkus Tober-Lau
A1 Gianluca Campo
A1 Marco Contoli
A1 Markus Ralser
A1 Florian Kurth
A1 Savino Spadaro
A1 Paola Rizzo
A1 Albert JR Heck
YR 2021
UL https://www.life-science-alliance.org/content/4/9/e202101099.abstract
AB Here, we recorded serum proteome profiles of 33 severe COVID-19 patients admitted to respiratory and intensive care units because of respiratory failure. We received, for most patients, blood samples just after admission and at two more later time points. With the aim to predict treatment outcome, we focused on serum proteins different in abundance between the group of survivors and non-survivors. We observed that a small panel of about a dozen proteins were significantly different in abundance between these two groups. The four structurally and functionally related type-3 cystatins AHSG, FETUB, histidine-rich glycoprotein, and KNG1 were all more abundant in the survivors. The family of inter-α-trypsin inhibitors, ITIH1, ITIH2, ITIH3, and ITIH4, were all found to be differentially abundant in between survivors and non-survivors, whereby ITIH1 and ITIH2 were more abundant in the survivor group and ITIH3 and ITIH4 more abundant in the non-survivors. ITIH1/ITIH2 and ITIH3/ITIH4 also showed opposite trends in protein abundance during disease progression. We defined an optimal panel of nine proteins for mortality risk assessment. The prediction power of this mortality risk panel was evaluated against two recent COVID-19 serum proteomics studies on independent cohorts measured in other laboratories in different countries and observed to perform very well in predicting mortality also in these cohorts. This panel may not be unique for COVID-19 as some of the proteins in the panel have previously been annotated as mortality markers in aging and in other diseases caused by different pathogens, including bacteria.