TY - JOUR T1 - The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.201900490 VL - 4 IS - 5 SP - e201900490 AU - Mariano F Zacarías-Fluck AU - Toni Jauset AU - Sandra Martínez-Martín AU - Jastrinjan Kaur AU - Sílvia Casacuberta-Serra AU - Daniel Massó-Vallés AU - Erika Serrano del Pozo AU - Génesis Martín-Fernández AU - Íñigo González-Larreategui AU - Sergio López-Estévez AU - Lamorna Brown-Swigart AU - Marie-Eve Beaulieu AU - Jonathan R Whitfield AU - Babita Madan AU - David M Virshup AU - Gerard I Evan AU - Laura Soucek Y1 - 2021/05/01 UR - https://www.life-science-alliance.org/content/4/5/e201900490.abstract N2 - The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. ER -