PT  - JOURNAL ARTICLE
AU  - Zacarías-Fluck, Mariano F
AU  - Jauset, Toni
AU  - Martínez-Martín, Sandra
AU  - Kaur, Jastrinjan
AU  - Casacuberta-Serra, Sílvia
AU  - Massó-Vallés, Daniel
AU  - Serrano del Pozo, Erika
AU  - Martín-Fernández, Génesis
AU  - González-Larreategui, Íñigo
AU  - López-Estévez, Sergio
AU  - Brown-Swigart, Lamorna
AU  - Beaulieu, Marie-Eve
AU  - Whitfield, Jonathan R
AU  - Madan, Babita
AU  - Virshup, David M
AU  - Evan, Gerard I
AU  - Soucek, Laura
TI  - The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets
AID  - 10.26508/lsa.201900490
DP  - 2021 May 01
TA  - Life Science Alliance
PG  - e201900490
VI  - 4
IP  - 5
4099  - http://www.life-science-alliance.org/content/4/5/e201900490.short
4100  - http://www.life-science-alliance.org/content/4/5/e201900490.full
SO  - Life Sci. Alliance2021 May 01; 4
AB  - The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.