%0 Journal Article %A Mariano F Zacarías-Fluck %A Toni Jauset %A Sandra Martínez-Martín %A Jastrinjan Kaur %A Sílvia Casacuberta-Serra %A Daniel Massó-Vallés %A Erika Serrano del Pozo %A Génesis Martín-Fernández %A Íñigo González-Larreategui %A Sergio López-Estévez %A Lamorna Brown-Swigart %A Marie-Eve Beaulieu %A Jonathan R Whitfield %A Babita Madan %A David M Virshup %A Gerard I Evan %A Laura Soucek %T The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets %D 2021 %R 10.26508/lsa.201900490 %J Life Science Alliance %P e201900490 %V 4 %N 5 %X The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets. %U https://www.life-science-alliance.org/content/lsa/4/5/e201900490.full.pdf