RT Journal Article SR Electronic T1 Renal CD169++ resident macrophages are crucial for protection against acute systemic candidiasis JF Life Science Alliance JO Life Sci. Alliance FD Life Science Alliance LLC SP e202000890 DO 10.26508/lsa.202000890 VO 4 IS 5 A1 Yi Juan Teo A1 See Liang Ng A1 Keng Wai Mak A1 Yolanda Aphrilia Setiagani A1 Qi Chen A1 Sajith Kumar Nair A1 Jianpeng Sheng A1 Christiane Ruedl YR 2021 UL https://www.life-science-alliance.org/content/4/5/e202000890.abstract AB Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for Candida persistence. Here, we describe a unique CD169++ TRM subset that controls Candida growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169++ TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-γ release and neutrophil ROS activity.