PT  - JOURNAL ARTICLE
AU  - Teo, Yi Juan
AU  - Ng, See Liang
AU  - Mak, Keng Wai
AU  - Setiagani, Yolanda Aphrilia
AU  - Chen, Qi
AU  - Nair, Sajith Kumar
AU  - Sheng, Jianpeng
AU  - Ruedl, Christiane
TI  - Renal CD169<sup>++</sup> resident macrophages are crucial for protection against acute systemic candidiasis
AID  - 10.26508/lsa.202000890
DP  - 2021 May 01
TA  - Life Science Alliance
PG  - e202000890
VI  - 4
IP  - 5
4099  - http://www.life-science-alliance.org/content/4/5/e202000890.short
4100  - http://www.life-science-alliance.org/content/4/5/e202000890.full
SO  - Life Sci. Alliance2021 May 01; 4
AB  - Disseminated candidiasis remains as the most common hospital-acquired bloodstream fungal infection with up to 40% mortality rate despite the advancement of medical and hygienic practices. While it is well established that this infection heavily relies on the innate immune response for host survival, much less is known for the protective role elicited by the tissue-resident macrophage (TRM) subsets in the kidney, the prime organ for Candida persistence. Here, we describe a unique CD169++ TRM subset that controls Candida growth and inflammation during acute systemic candidiasis. Their absence causes severe fungal-mediated renal pathology. CD169++ TRMs, without being actively involved in direct fungal clearance, increase host resistance by promoting IFN-γ release and neutrophil ROS activity.