RT Journal Article
SR Electronic
T1 Insulin signaling mediates neurodegeneration in glioma
JF Life Science Alliance
JO Life Sci. Alliance
FD Life Science Alliance LLC
SP e202000693
DO 10.26508/lsa.202000693
VO 4
IS 3
A1 Jarabo, Patricia
A1 de Pablo, Carmen
A1 Herranz, Héctor
A1 Martín, Francisco Antonio
A1 Casas-Tintó, Sergio
YR 2021
UL http://www.life-science-alliance.org/content/4/3/e202000693.abstract
AB Cell to cell communication facilitates tissue development and physiology. Under pathological conditions, brain tumors disrupt glia-neuron communication signals that in consequence, promote tumor expansion at the expense of surrounding healthy tissue. The glioblastoma is one of the most aggressive and frequent primary brain tumors. This type of glioma expands and infiltrates into the brain, causing neuronal degeneration and neurological decay, among other symptoms. Here, we describe in a Drosophila model how glioblastoma cells produce ImpL2, an antagonist of the insulin pathway, which targets neighboring neurons and causes mitochondrial disruption as well as synapse loss, both early symptoms of neurodegeneration. Furthermore, glioblastoma progression requires insulin pathway attenuation in neurons. Restoration of neuronal insulin activity is sufficient to rescue synapse loss and to delay the premature death caused by glioma. Therefore, signals from glioblastoma to neuron emerge as a potential field of study to prevent neurodegeneration and to develop anti-tumoral strategies.