PT  - JOURNAL ARTICLE
AU  - Patricia Jarabo
AU  - Carmen de Pablo
AU  - Héctor Herranz
AU  - Francisco Antonio Martín
AU  - Sergio Casas-Tintó
TI  - Insulin signaling mediates neurodegeneration in glioma
AID  - 10.26508/lsa.202000693
DP  - 2021 Mar 01
TA  - Life Science Alliance
PG  - e202000693
VI  - 4
IP  - 3
4099  - https://www.life-science-alliance.org/content/4/3/e202000693.short
4100  - https://www.life-science-alliance.org/content/4/3/e202000693.full
SO  - Life Sci. Alliance2021 Mar 01; 4
AB  - Cell to cell communication facilitates tissue development and physiology. Under pathological conditions, brain tumors disrupt glia-neuron communication signals that in consequence, promote tumor expansion at the expense of surrounding healthy tissue. The glioblastoma is one of the most aggressive and frequent primary brain tumors. This type of glioma expands and infiltrates into the brain, causing neuronal degeneration and neurological decay, among other symptoms. Here, we describe in a Drosophila model how glioblastoma cells produce ImpL2, an antagonist of the insulin pathway, which targets neighboring neurons and causes mitochondrial disruption as well as synapse loss, both early symptoms of neurodegeneration. Furthermore, glioblastoma progression requires insulin pathway attenuation in neurons. Restoration of neuronal insulin activity is sufficient to rescue synapse loss and to delay the premature death caused by glioma. Therefore, signals from glioblastoma to neuron emerge as a potential field of study to prevent neurodegeneration and to develop anti-tumoral strategies.