TY - JOUR T1 - The actin regulator profilin 1 is functionally associated with the mammalian centrosome JF - Life Science Alliance JO - Life Sci. Alliance DO - 10.26508/lsa.202000655 VL - 4 IS - 1 SP - e202000655 AU - Michaela Nejedlá AU - Anastasiya Klebanovych AU - Vadym Sulimenko AU - Tetyana Sulimenko AU - Eduarda Dráberová AU - Pavel Dráber AU - Roger Karlsson Y1 - 2021/01/01 UR - https://www.life-science-alliance.org/content/4/1/e202000655.abstract N2 - Profilin 1 is a crucial actin regulator, interacting with monomeric actin and several actin-binding proteins controlling actin polymerization. Recently, it has become evident that this profilin isoform associates with microtubules via formins and interferes with microtubule elongation at the cell periphery. Recruitment of microtubule-associated profilin upon extensive actin polymerizations, for example, at the cell edge, enhances microtubule growth, indicating that profilin contributes to the coordination of actin and microtubule organization. Here, we provide further evidence for the profilin-microtubule connection by demonstrating that it also functions in centrosomes where it impacts on microtubule nucleation. ER -